Study of Non-Thermal Plasma to Improve Healing and Safety After Thyroid Surgery Comparing Plasma Treatment to Standard Wound Care

What this Trial Is About

Researchers are evaluating the use of non-thermal plasma NTP to improve wound healing and reduce complications after thyroid surgery. This study focuses on patients undergoing total or subtotal thyroidectomy and aims to see if NTP can speed up tissue repair, lower inflammation and pain, and prevent complications like infections. The safety of helium-based NTP near important neck nerves and blood vessels is also being assessed. Participants are randomly assigned to one of two groups. The experimental group receives a standardized treatment with helium-based NTP applied to the surgical area before closing and then again on the sutured incision. This involves specific exposure times targeting hemostasis, nerve protection, and potential cancer cell removal if needed. The control group receives standard surgical wound care, including routine suturing and dressings, without NTP treatment. Participants will be followed for up to 12 weeks after surgery with regular assessments of wound healing speed, pain levels, inflammation markers, and scar quality. Pain is measured frequently in the first two weeks, and complications are tracked for 28 days. The study also monitors analgesic use and long-term scar outcomes to evaluate NTPs impact on recovery and safety.

Safety and Efficacy of NTP in Thyroid Surgery: Pilot Study on Morbidity Prevention and Adjuvant Oncological Control