Actively Recruiting
The Safety and Efficacy of Rapamycin on Communicating Hydrocephalus Secondary to Intraventricular Hemorrhage
Led by Beijing Tiantan Hospital · Updated on 2024-08-21
53
Participants Needed
1
Research Sites
47 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This prospective, multicenter, open-label clinical trial is designed to evaluate the safety and efficacy of rapamycin in the treatment of communicating hydrocephalus secondary to intraventricular hemorrhage. Additionally, the underlying pathogenic mechanisms associated with this particular type of hydrocephalus will be investigated in greater depth, and populations that may benefit from rapamycin therapy will be identified.
CONDITIONS
Official Title
The Safety and Efficacy of Rapamycin on Communicating Hydrocephalus Secondary to Intraventricular Hemorrhage
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with ventricular enlargement from intraventricular hemorrhage showing new gait disturbances, cognitive problems, or urinary incontinence after symptom remission, and brain imaging with Evans index 60.3
- Age between 18 and 70 years
- Signed informed consent form
You will not qualify if you...
- Participation in another medical trial
- Other diseases affecting symptoms like walking, cognition, or urinary control
- Allergy to rapamycin
- Reduced liver function with elevated INR or alanine transaminase over 1.5 times normal
- Reduced kidney function with GFR less than 50
- Taking strong CYP3A4/5 inducers or inhibitors such as diltiazem, ketoconazole, or rifampicin
- Active or uncontrolled chronic infections
- Pregnant or breastfeeding women
- Bedridden patients or those needing long-term urinary catheters
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 100070
Actively Recruiting
Research Team
R
Runfa Tian, MD
CONTACT
G
Guoyi Gao, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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