Actively Recruiting
Safety and Efficacy of Tissue Engineered Endothelial Keratoplasty
Led by Singapore Eye Research Institute · Updated on 2025-09-12
30
Participants Needed
1
Research Sites
547 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Assessment of safety and efficacy of tissue-engineered corneal endothelial graft material generated using cultured human corneal endothelial cells for tissue-engineered endothelial keratoplasty (TE-EK).
CONDITIONS
Official Title
Safety and Efficacy of Tissue Engineered Endothelial Keratoplasty
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with mild to moderate corneal endothelial decompensation or bullous keratopathy with minimal corneal stromal scarring
- Conditions include Fuchs' endothelial dystrophy and irreversible post-surgical corneal decompensation (all forms of pseudophakic or aphakic bullous keratopathy)
- Age between 21 and 80 years
You will not qualify if you...
- Severe or late-stage corneal decompensation with severe corneal stromal scarring unsuitable for TE-EK surgery
- Complex anterior segment complications preventing successful TE-EK procedure
- Other endothelial dystrophies, traumatic corneal decompensation, or post-inflammatory corneal decompensation
- Corneal decompensation related to post-laser iridotomy or glaucoma
- Unwillingness to participate in the clinical trial
- Age below 21 years or above 80 years
- Pregnancy
- Cognitive impairment
- Prisoner status
- Allergy to antibiotics
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Singapore Eye Research Institute
Singapore, Singapore
Actively Recruiting
Research Team
L
Lee Yan Lim
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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