Actively Recruiting
Safety and Feasibility of Temporal Interference Brain Stimulation for Treatment in Psychiatric Disorders
Led by Taipei Veterans General Hospital, Taiwan · Updated on 2026-02-09
80
Participants Needed
1
Research Sites
83 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to validate if temporal interference brain stimulation (TIBS) is safe in healthy volunteers aged 20 to 65. The main questions it aims to answer are: * Is it safe to apply TIBS intervention to the left hippocampus in healthy participants? * Is it safe to apply TIBS intervention to the left insula in healthy participants? * Is it safe to apply TIBS intervention to the left anterior cingulate cortex in healthy participants? * Is it safe to apply TIBS intervention to the right inferior frontal cortex in healthy participants? Participants will: * Be Randomly allocated to either sham-first group or treat first-group, stratified by stimulated brain region, following a crossover-controlled experimental design * Complete baseline cognitive evaluations and mental status assessments, and undergo a baseline MRI scan on the same day * Receive stimulation for 5 consecutive days, followed by a 2-days washout period, then complete the remaining 5 days of stimulation. * Complete post-intervention cognitive evaluations and mental status assessments, and undergo a post-intervention MRI scan on the same day
CONDITIONS
Official Title
Safety and Feasibility of Temporal Interference Brain Stimulation for Treatment in Psychiatric Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy adults from the community
- Age between 20 and 65 years old
- No diagnosis of severe psychiatric disorders
- No family history of psychiatric diseases
You will not qualify if you...
- Age below 20 years old or above 65 years old
- Currently prescribed any medication
- Diagnosis of psychiatric disorders (e.g., Major Depressive Disorder, Bipolar Disorder, Schizophrenia)
- Diagnosis of neurological disorders (e.g., Dementia, Stroke, Parkinson's disease)
- History of substance abuse
- Diagnosis of cancer or malignant tumors
- Chronic kidney failure or undergoing hemodialysis
- Pregnant or breastfeeding
- Severe arrythmia, presence of pacemaker, or metal implants in the brain
- Claustrophobia
- History or family history of seizure
- History of syncope
- Organic brian disease, brian trauma, or history of neurosurgery
- Received electroconvulsive therapy or repetitive transcranial magnetic stimulation within the past month
- Skin disorders (e.g., dermatitis, psoriasis, eczema)
- Currently participating in other clinical interventional trials
- Presence of any metal implants or devices affected by electromagnetic fields
AI-Screening
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Trial Site Locations
Total: 1 location
1
Taipei Veterans General Hospital
Taipei, Taiwan, 112
Actively Recruiting
Research Team
A
Albert Chih-Chieh Yang, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
8
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