Actively Recruiting
A Safety and Immunogenicity Study of CHIKV VLP Vaccine in Children.
Led by Bavarian Nordic · Updated on 2026-03-24
720
Participants Needed
15
Research Sites
182 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this multi-center, randomized, double-blind, placebo-controlled study is to evaluate the safety and immunogenicity of CHIKV VLP Vaccine in children 1 to \<12 years of age.
CONDITIONS
Official Title
A Safety and Immunogenicity Study of CHIKV VLP Vaccine in Children.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males or females between 1 and less than 12 years of age on the day of vaccination
- Body weight of at least 6.5 kg
- Generally in good health based on medical history and physical exam
- Able and willing to provide informed assent; caregiver able and willing to provide informed consent
- Able and willing to complete scheduled visits and follow study procedures
You will not qualify if you...
- Participation or planned participation in another investigational study within 30 days before vaccination and during the study
- Current acute illness, with or without fever
- Current or recent chikungunya virus infection based on specific tests (for participants in the Philippines)
- Known or suspected allergy or anaphylaxis to vaccine components
- Known congenital or acquired immune deficiency or immunosuppressive condition
- Use of systemic immunomodulatory or immunosuppressive medications within 180 days prior to screening through Day 22
- Receipt or planned receipt of immunoglobulin within 180 days prior to screening through study duration
- Receipt or planned receipt of certain vaccines within specified timeframes before and after vaccination
- Known infection with HIV, hepatitis C, or hepatitis B virus (except certain antibody-positive cases)
- Bleeding disorder or recent use of anticoagulants contraindicating intramuscular vaccination
- Receipt or planned receipt of blood products within 90 days before vaccination through study duration
- Onset of menarche prior to vaccination
- Planned medical or surgical procedure that could affect participation
- Immediate family members of study staff, employees, contractors, or those with financial interest in the study
- Any other medical condition that could affect participation or study conduct, including severe malnutrition
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 15 locations
1
ARK Clinical Research, LLC
Fountain Valley, California, United States, 92708
Actively Recruiting
2
Emerson Clinical Research Institute- DC
Washington D.C., District of Columbia, United States, 20009
Actively Recruiting
3
Acevedo Clinical Research
Miami, Florida, United States, 33142
Actively Recruiting
4
Hope Research Network
Miami, Florida, United States, 33166
Actively Recruiting
5
Velocity Clinical Research-Omaha
Omaha, Nebraska, United States, 68134
Actively Recruiting
6
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
Actively Recruiting
7
KidCare Pediatrics
Beaumont, Texas, United States, 77706
Actively Recruiting
8
Velocity Clinical Research - Salt Lake City
West Jordan, Utah, United States, 84088
Actively Recruiting
9
CARE CT Group Inc.
Dasmariñas, Cavite, Philippines, 4114
Actively Recruiting
10
HIMC Research and Development on Medical Sciences
Imus, Cavite, Philippines, 4103
Actively Recruiting
11
Silang Specialist Medical Center
Silang, Cavite, Philippines, 4118
Actively Recruiting
12
University of Perpetual Help DALTA Medical Center, Biomedical Research Institute
Las Piñas, National Capital Region, Philippines, 1740
Not Yet Recruiting
13
Institute of Child Health and Human Development, University of the Philippines
Manila, National Capital Region, Philippines, 1000
Actively Recruiting
14
University of the Philippines-Philippine General Hospital
Manila, Philippines, 100
Not Yet Recruiting
15
CMRC Headlands LLC
San Juan, Puerto Rico, Puerto Rico, 918
Actively Recruiting
Research Team
P
Priya Uppin
CONTACT
F
Faye Cross
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
4
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