Actively Recruiting
Safety, Pharmacokinetics, and Efficacy of AT 1501 in Patients Undergoing Kidney Transplant
Led by Eledon Pharmaceuticals · Updated on 2025-06-29
48
Participants Needed
9
Research Sites
254 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will evaluate the safety, PK, and efficacy of AT 1501 in patients undergoing kidney transplantation.
CONDITIONS
Official Title
Safety, Pharmacokinetics, and Efficacy of AT 1501 in Patients Undergoing Kidney Transplant
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female 18 years of age or older
- Recipient of their first kidney transplant from a living or deceased donor
- Agree to use contraception during and for at least 90 days after the last dose of study drug
You will not qualify if you...
- Planned induction therapy other than study-assigned rATG
- Currently treated with systemic immunosuppressive regimens except prednisone 5 mg or less daily
- Previous treatment with AT 1501 or any anti CD40LG therapy
- History of bone marrow transplant, any other solid organ transplant, multi-organ or dual kidney transplant
- Receiving a kidney with expected cold ischemia time over 30 hours
- Receiving kidney from donor meeting Donation after Cardiac Death or Extended Criteria Donor definitions
- Receiving kidney from donor with blood group incompatibility or certain age and health criteria
- Receiving kidney from a donor who is HLA identical (two haplotype match or zero mismatch)
- Medical conditions requiring chronic steroids over 5 mg prednisone or equivalent daily
- History of thromboembolic events, known hypercoagulable state, or requiring long-term anticoagulation
- Positive T- or B-cell crossmatch due to HLA antibodies or donor-specific antibodies at screening
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 9 locations
1
University of Cincinnati
Cincinnati, Ohio, United States, 45267
Actively Recruiting
2
Royal Prince Alfred Hospital
Camperdown, New South Wales, Australia, 2050
Actively Recruiting
3
Royal Adelaide Hospital
Adelaide, South Australia, Australia, SA 5000
Actively Recruiting
4
Fundação Oswaldo Ramos - Hospital do Rim
São Paulo, Brazil
Actively Recruiting
5
Providence Health Care - St. Paul's Hospital
Vancouver, British Columbia, Canada, V6Z 1Y6
Actively Recruiting
6
Vancouver General Hospital
Vancouver, British Columbia, Canada, V6Z 1Y6
Actively Recruiting
7
McGill University Health Care Centre
Montreal, Quebec, Canada, H4A 3J1
Actively Recruiting
8
Liverpool University Hospitals NHS Foundation Trust - Royal Liverpool University Hospital
Liverpool, United Kingdom, L78XP
Actively Recruiting
9
Oxford University Hospitals NHS Foundation Trust - John Radcliffe Hospital
Oxford, United Kingdom, OX3 9DU
Actively Recruiting
Research Team
E
Eledon Pharmaceuticals
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here