Actively Recruiting
Safety of Short-course of NSAIDs in Pediatric Patients With CKD
Led by University of Colorado, Denver · Updated on 2025-10-22
80
Participants Needed
1
Research Sites
97 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine if non-steroidal anti-inflammatory (NSAID) use in the postoperative setting increases the risk of acute kidney injury (AKI) in pediatric patients with mild-to-moderate chronic kidney disease (CKD). The investigators hypothesize that there is no increased risk. This will be a limited pilot study within a Pediatric Urology population, intended to inform future work in a larger patient population.
CONDITIONS
Official Title
Safety of Short-course of NSAIDs in Pediatric Patients With CKD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients over 18 months of age
- Diagnosis of chronic kidney disease stages 2 to 3a, confirmed by cystatin C lab testing within 6 months before surgery
You will not qualify if you...
- Diagnosis of chronic kidney disease stage 1 or stages 4 to 5
- Use of ACE inhibitors, angiotensin receptor blockers, diuretics, or trimethoprim at home
- Received intravenous contrast dye in the last 30 days
- History of kidney transplant, diabetes, hypertension, nephrotic syndrome, heart failure, asthma, or hyperthyroidism
- History of high potassium levels (hyperkalemia)
- Recent exposure to glucocorticoids
- Surgery for cancer-related reasons
- Ongoing viral or fungal infections, or receiving chemotherapy
- Allergy to non-steroidal anti-inflammatory drugs (NSAIDs)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Children's Hospital Colorado
Aurora, Colorado, United States, 80045
Actively Recruiting
Research Team
K
Kyle Rove, MD
CONTACT
J
Jennifer Pyrzanowski, MSPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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