Actively Recruiting
A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes
Led by Vertex Pharmaceuticals Incorporated · Updated on 2026-03-17
52
Participants Needed
29
Research Sites
482 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will evaluate the safety, tolerability and efficacy of VX-880 infusion in participants with Type 1 diabetes (T1D) and impaired awareness of hypoglycemia (IAH) and severe hypoglycemia.
CONDITIONS
Official Title
A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical history of Type 1 diabetes with more than 5 years of insulin dependence
- At least two episodes of documented severe hypoglycemia in the 12 months prior to enrollment
- Stable diabetic treatment
- Consistent use of continuous glucose monitor for at least 3 months before screening and willingness to use it during the study
You will not qualify if you...
- Prior islet cell transplant, organ transplant, or cell therapy
- Other protocol defined inclusion/exclusion criteria may apply
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 29 locations
1
City of Hope
Duarte, California, United States, 91010
Actively Recruiting
2
University of California San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
3
UHealth Diabetes Research Institute
Miami, Florida, United States, 33136
Actively Recruiting
4
Northwestern Organ Transplant Center
Chicago, Illinois, United States, 60611
Completed
5
University of Chicago
Chicago, Illinois, United States, 60637
Actively Recruiting
6
Johns Hopkins University
Baltimore, Maryland, United States, 21287
Actively Recruiting
7
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
8
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
9
University of Pittsburgh Medical Center Montefiore
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
10
Baylor Scott and White Research Institute
Dallas, Texas, United States, 75246
Actively Recruiting
11
VCU Medical Center, Richmond
Richmond, Virginia, United States, 23298
Actively Recruiting
12
University of Wisconsin
Madison, Wisconsin, United States, 53792
Actively Recruiting
13
University of Alberta, Edmonton
Edmonton, Canada
Actively Recruiting
14
McGill University Health Centre
Montreal, Canada
Actively Recruiting
15
Toronto General Hospital (TGH)
Toronto, Canada
Actively Recruiting
16
Vancouver General Hospital
Vancouver, Canada
Actively Recruiting
17
CHU Lille
Lille, France
Actively Recruiting
18
Centre de recherche en Biomédecine de Strasbourg
Strasbourg, France
Actively Recruiting
19
Dresden Center for Islet Transplantation
Dresden, Germany
Actively Recruiting
20
IRCCS Ospedale San Raffaele
Milan, Italy
Actively Recruiting
21
Leiden University
Leiden, Netherlands
Actively Recruiting
22
Oslo University Hospital
Oslo, Norway
Actively Recruiting
23
King Abdullah International Medical Research Center (KAIMRC) - Riyadh - Endocrinology
Riyadh, Saudi Arabia
Actively Recruiting
24
King Faisal Specialist Hospital & Research Centre - Riyadh - Endocrinology
Riyadh, Saudi Arabia
Actively Recruiting
25
Hopiteaux Universitaires de Geneve
Geneva, Switzerland
Actively Recruiting
26
Churchill Hospital
Headington, Oxford, United Kingdom
Actively Recruiting
27
Royal Infirmary of Edinburgh
Edinburgh, United Kingdom
Actively Recruiting
28
Cardiovascular, Metabolic Medicine and Sciences, King's College London
London, United Kingdom
Actively Recruiting
29
The Newcastle upon Tyne Hospitals NHS Foundation Trust
Newcastle upon Tyne, United Kingdom
Actively Recruiting
Research Team
M
Medical Information
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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