Safety and Tolerability of High-Frequency Transcranial Magnetic Stimulation for Spinal Muscular Atrophy Starting at Age 12

What this Trial Is About

Researchers are studying the safety and tolerability of low motoneuron stimulation using high-frequency repetitive transcranial magnetic stimulation HF-rTMS in people with spinal muscular atrophy SMA. SMA is a condition where muscle weakness occurs due to nerve problems, and exercise may help prevent muscle loss. However, regular exercise can be difficult for people with SMA due to physical and psychological challenges. This trial explores whether HF-rTMS can mimic exercise effects on muscles, especially for those who cannot perform physical activities easily. Participants will receive HF-rTMS targeting the primary motor cortex of the limbs at a frequency above 5 Hz and intensity of 90-100% of their resting motor threshold. The treatment involves up to 10 sessions, each delivering up to 2400 stimuli. Additionally, cerebrospinal fluid will be collected via lumbar puncture before and after the treatment to measure specific proteins related to SMA. During the study, participants will undergo assessments of motor function using several scales and tests, including the Motor Function Measure Scale, the Revised Upper Limb Module, the Hammersmith Functional Motor Scale - Expanded, and the 6-Minute Walk Test. These will be performed before the first TMS session and shortly after the last session. The study evaluates changes in motor abilities and monitors safety and tolerability throughout the trial, which runs until January 2026.

Safety and Tolerability of Low Motoneuron Stimulation Via Transcranial Magnetic Stimulation in Spinal Muscular Atrophy