Actively Recruiting
Safety and Tolerability of Low Motoneuron Stimulation Via Transcranial Magnetic Stimulation in Spinal Muscular Atrophy
Led by Charitable Foundation Children with Spinal Muscular Atrophy · Updated on 2025-06-18
20
Participants Needed
1
Research Sites
32 weeks
Total Duration
On this page
Sponsors
C
Charitable Foundation Children with Spinal Muscular Atrophy
Lead Sponsor
P
P.V. Voloshyn Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine
Collaborating Sponsor
AI-Summary
What this Trial Is About
There is a general physiological rule that any organ or system needs some minimal amount of activity to prevent its atrophy or degeneration. Although the relevance of that rule to exercises in neuromuscular patients and for SMA in particular is not definitely proven, clinical observations seem to support this assumption. Also there are several experimental studies which provide additional support for utility of exercise for SMA. However, making regular exercises may be very challenging with SMA not only due to physical limitations, but due to psychological either. While being considered as safe and well tolerated intervention, TMS is able to mimic effects of real physical exercises, at least at the level of low motoneuron, it also provides several advantages. For example, possibility to exercise non-collaborative infants, minimization of psychological motivation impact in adults and/or ability to involve very weak muscle groups.
CONDITIONS
Official Title
Safety and Tolerability of Low Motoneuron Stimulation Via Transcranial Magnetic Stimulation in Spinal Muscular Atrophy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of 5q-autosomal recessive spinal muscular atrophy confirmed by DNA test
- Informed consent provided
- Minimum score of 1 on Entry Item "A" of the Revised Upper Limb Module scale, indicating ability to use hands for simple tasks
You will not qualify if you...
- Severe joint contractures affecting ability to perform study measures
- Deconditioned respiratory system as determined by the study physician
- Behavioral or cognitive problems preventing participation according to the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
P.V. Voloshyn Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine
Kharkiv, Kharkivs’ka Oblast’, Ukraine, 61068
Actively Recruiting
Research Team
V
Vitaliy M Matyushenko
CONTACT
A
Andriy V Shatillo, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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