Actively Recruiting
Safety and Tolerability Study of a Novel Bioartificial Liver in Liver Failure and Small-for-Size Syndrome
Led by Beijing Friendship Hospital · Updated on 2026-04-20
12
Participants Needed
1
Research Sites
160 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate the safety and tolerability of a novel bioartificial liver (CiPS-BAL) in patients with liver failure or small-for-size syndrome. The study will also collect preliminary data on clinical outcomes and laboratory parameters during treatment. The main questions it aims to answer are: Is the novel bioartificial liver system safe and well tolerated in patients with liver failure or small-for-size syndrome? What effects does the treatment have on liver function and other clinical and laboratory indicators? Researchers will treat participants with the CiPS-BAL system, which uses hepatocytes derived from chemically induced pluripotent stem cells (CiPS) within a bioartificial liver device.
CONDITIONS
Official Title
Safety and Tolerability Study of a Novel Bioartificial Liver in Liver Failure and Small-for-Size Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with liver failure (including acute, subacute/acute-on-chronic, and chronic liver failure) or small-for-size syndrome
You will not qualify if you...
- Presence of severe extrahepatic systemic end-stage diseases
- Uncontrollable infection or active bleeding
- Pregnant or breastfeeding women
- History of allergy or known severe hypersensitivity to CiPSC-derived cell products or blood products
- Peripheral vascular collapse leading to inability to obtain venous access or collect blood
- Unable or unwilling to provide informed consent or unable to comply with study requirements
- Unwilling to receive CiPSC-based therapy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Beijing Friendship Hospital
Beijing, China, 101102
Actively Recruiting
Research Team
W
Wan-Ting Zhang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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