Actively Recruiting
The Safety/Efficacy of hUC Mesenchymal Stem Cells（19#iSCLife®-OA） Therapy for Patients With Osteoarthritis
Led by Sclnow Biotechnology Co., Ltd. · Updated on 2025-12-04
60
Participants Needed
1
Research Sites
430 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is verify the efficacy and safety of Human Umbilical Cord Mesenchymal Stem Cells (UC-MSC) therapy for patients with Osteoarthritis, and in addition, provide basis for exploring the treatment regimen of UC-MSC therapy in different degree of cartilage defect disease
CONDITIONS
Official Title
The Safety/Efficacy of hUC Mesenchymal Stem Cells（19#iSCLife®-OA） Therapy for Patients With Osteoarthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of knee osteoarthritis with Kellgren and Lawrence Grade 2-3
- Confirmed cartilage injury by MRI, including partial or full-thickness damage
- Age under 70 years with no serious organ dysfunction
- Knee pain lasting more than 2 years or poor response to conservative treatment
- Knee pain score of 4 or higher on the Visual Analog Scale
- Normal liver and kidney function
- No history of gout, rheumatoid arthritis, or autoimmune diseases
- Able to understand and sign the study consent form
You will not qualify if you...
- Refusal or inability to sign the consent form or to attend follow-up visits
- Age over 70 or under 70 with multiple organ failure
- Unstable vital signs such as breathing, blood pressure, or pulse
- Knee ligament rupture or laxity
- Serious bleeding or poor blood clotting (PTA less than 35%)
- Pregnant, breastfeeding, or positive pregnancy test within 7 days before treatment
- Participation in other clinical trials within the last 3 months
- Progressive malignant tumors
- Shock or critical illness
- Mental illness preventing participation
- History of knee joint infection, surgery, or radiotherapy
- Use of immunosuppressive drugs in the last 6 weeks
- Injection of hormones or sodium hyaluronate into the joint in the last 3 months
- Body mass index over 35
- Skin disease around the knee joint
- Immunodeficiency or long-term immunosuppressive treatment
- Serious infections
- Other conditions deemed unsuitable by the doctor
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Xiangya Hospital Central South University
Changsha, Hunan, China, 410008
Actively Recruiting
Research Team
L
Lei Guo
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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