Actively Recruiting
Salivary Cortisol Levels in Children With Molar Incisor Hypomineralization
Led by Lokman Hekim University · Updated on 2026-02-09
90
Participants Needed
1
Research Sites
12 weeks
Total Duration
On this page
Sponsors
L
Lokman Hekim University
Lead Sponsor
T
The Scientific and Technological Research Council of Turkey
Collaborating Sponsor
AI-Summary
What this Trial Is About
Molar incisor hypomineralization (MIH) is a developmental condition that affects the enamel of permanent molars and incisors in children and may cause tooth sensitivity, discomfort, and difficulties during dental treatment. These problems can increase dental anxiety and lead to physiological stress responses during dental visits. The purpose of this observational study is to evaluate physiological stress responses in children with MIH by measuring salivary cortisol levels, heart rate, and oxygen saturation, and to compare these findings with those of children without MIH. A total of 90 children aged 8 to 12 years will participate in the study, including 45 children diagnosed with MIH and 45 healthy control participants. Participation involves no treatment or intervention beyond a routine clinical dental examination. Heart rate and oxygen saturation will be measured during the dental visit, and saliva samples will be collected immediately after the examination using a non-invasive method to assess cortisol levels. The results of this study may contribute to a better understanding of stress responses in children with MIH and support the development of more individualized and anxiety-sensitive dental care approaches.
CONDITIONS
Official Title
Salivary Cortisol Levels in Children With Molar Incisor Hypomineralization
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged between 8 and 12 years
- Children diagnosed with molar incisor hypomineralization (MIH) according to the European Academy of Paediatric Dentistry (EAPD) criteria or healthy children without MIH
- Ability to cooperate sufficiently to complete the clinical dental examination and study procedures
- Written informed consent obtained from a parent or legal guardian
You will not qualify if you...
- Presence of systemic, hormonal, or metabolic diseases
- Regular use of medications known to affect salivary cortisol levels or cardiovascular parameters, such as corticosteroids or beta-blockers
- History of systemic conditions that may influence stress response
- Refusal of participation by the child or parent/legal guardian
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Lokman Hekim University, Faculty of Dentistry
Ankara, Ankara, Turkey (Türkiye), 06510
Actively Recruiting
Research Team
H
Hamide Comert, DDS, PhD
CONTACT
M
Merve Ozdemir, DDS, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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