Global burden of molar incisor hypomineralization.
Falk Schwendicke, Karim Elhennawy, Seif Reda...
https://pubmed.ncbi.nlm.nih.gov/29221956Actively Recruiting
Age: 8Years - 12Years
All Genders
Healthy Volunteers
ID07389148
Evaluation of Salivary Cortisol Levels and Physiological Stress Parameters in Children With Molar Incisor Hypomineralization: A Comparative Observational Study
Led by Lokman Hekim University · Updated on 2026-02-09
90
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
Sponsors
L
Lokman Hekim University
Lead Sponsor
T
The Scientific and Technological Research Council of Turkey
Collaborating Sponsor
AI-Summary
What this Trial Is About
Molar incisor hypomineralization (MIH) is a condition affecting the enamel of permanent molars and incisors in children, often causing tooth sensitivity, discomfort, and challenges during dental care. This condition may increase dental anxiety and trigger physiological stress responses. This observational study aims to evaluate such stress responses in children with MIH by measuring salivary cortisol levels, heart rate, and oxygen saturation, then comparing these with children without MIH. The study includes two groups of children aged 8 to 12 years: one group diagnosed with MIH and a healthy control group matched by age and sex. All participants will undergo a routine clinical dental examination without any treatment or intervention. Physiological stress parameters will be recorded during the visit, and saliva samples for cortisol analysis will be collected immediately after the examination using a non-invasive method. Participants will have their heart rate and oxygen saturation monitored during the dental visit, and saliva will be collected to measure cortisol levels. These assessments will help researchers understand stress responses related to dental anxiety in children with MIH. The study procedures are designed to be non-invasive and standardized. Participation lasts for the duration of the dental visit, and results may support the development of more anxiety-sensitive dental care approaches.
CONDITIONS
Brief Title
Salivary Cortisol Levels in Children With Molar Incisor Hypomineralization
Who Can Participate
Age: 8Years - 12Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Children aged between 8 and 12 years
- Children diagnosed with molar incisor hypomineralization (MIH) according to the European Academy of Paediatric Dentistry (EAPD) criteria or healthy children without MIH
- Ability to cooperate sufficiently to complete the clinical dental examination and study procedures
- Written informed consent obtained from a parent or legal guardian
You will not qualify if you...
- Presence of systemic, hormonal, or metabolic diseases
- Regular use of medications known to affect salivary cortisol levels or cardiovascular parameters (e.g., corticosteroids, beta-blockers)
- History of systemic conditions that may influence stress response
- Refusal of participation by the child or parent/legal guardian
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - 1 day
Participants undergo a routine clinical dental examination during which physiological stress parameters such as heart rate and oxygen saturation are recorded. Saliva samples are collected immediately after the examination to assess cortisol levels.
1 visit (in-person)
Long-term Monitoring
Duration - Up to study completion date
Participants are observed to understand physiological stress responses associated with molar incisor hypomineralization over time.
No additional visits required
Trial Site Locations
Total: 1 location
1
Lokman Hekim University, Faculty of Dentistry
Ankara, Ankara, Turkey (Türkiye), 06510
Actively Recruiting
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Research Team
H
Hamide Comert, DDS, PhD
M
Merve Ozdemir, DDS, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Published Research Related To This Trial
Judgement criteria for molar incisor hypomineralisation (MIH) in epidemiologic studies: a summary of the European meeting on MIH held in Athens, 2003.
K L Weerheijm, M Duggal, I Mejàre...
https://pubmed.ncbi.nlm.nih.gov/14529329Can molar incisor hypomineralization cause dental fear and anxiety or influence the oral health-related quality of life in children and adolescents?-a systematic review.
B Jälevik, N Sabel, A Robertson
https://pubmed.ncbi.nlm.nih.gov/34110616Salivary Cortisol as a Biomarker for Assessing Fear and Anxiety in Patients with Molar-Incisor Hypomineralization.
Laura-Roxana Contac, Silvia Izabella Pop, Minodora Dobreanu...
https://pubmed.ncbi.nlm.nih.gov/40002640