Actively Recruiting
Salvage Radiation Therapy in Treating Patients With Metastatic Cancer That Has Progressed After Systemic Immunotherapy
Led by M.D. Anderson Cancer Center · Updated on 2025-11-10
230
Participants Needed
5
Research Sites
522 weeks
Total Duration
On this page
Sponsors
M
M.D. Anderson Cancer Center
Lead Sponsor
A
Artidis
Collaborating Sponsor
AI-Summary
What this Trial Is About
This phase II trial studies the side effects and best dose of radiation therapy and to see how well it works in treating patients with cancer that has spread to other places in the body (metastatic) or has increased in size after being treated with immunotherapy. Giving radiation therapy may help to control the cancer after the disease has gotten worse after receiving immunotherapy in patients with cancer that has spread to the other places in the body.
CONDITIONS
Official Title
Salvage Radiation Therapy in Treating Patients With Metastatic Cancer That Has Progressed After Systemic Immunotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pathologically confirmed diagnosis of cancer.
- Progressive disease after prior immunotherapy or clinical need for salvage radiation as decided by physician.
- Previous disease progression on immunotherapy or cell-based therapy.
- At least one metastatic site suitable for radiation treatment.
- Willing and able to provide written informed consent.
- Age 18 years or older at consent.
- Performance status of 0 to 2 on the ECOG scale.
- Female participants of childbearing potential must have a negative pregnancy test within 28 days before radiation.
- Prior radiation allowed if high dose areas do not overlap or only low dose overlaps.
- Non-English speakers are eligible.
You will not qualify if you...
- Active scleroderma, lupus, or other rheumatologic diseases that prevent safe radiation.
- Prior radiation within 3 months with overlapping high dose areas.
- Not recovered from previous treatment side effects above grade 1, except certain stable or managed toxicities.
- Active infection requiring intravenous therapy or hospitalization.
- Psychiatric or substance abuse disorders interfering with trial participation.
- Pregnant or planning pregnancy during the study period through 60 days after last radiation.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
MD Anderson in The Woodlands
Conroe, Texas, United States, 77384
Actively Recruiting
2
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
3
MD Anderson West Houston
Houston, Texas, United States, 77079
Actively Recruiting
4
MD Anderson League City
League City, Texas, United States, 77573
Actively Recruiting
5
MD Anderson in Sugar Land
Sugar Land, Texas, United States, 77478
Actively Recruiting
Research Team
J
James Welsh, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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