Actively Recruiting
Same-day Radioembolization for Large HCC
Led by Seoul National University Hospital · Updated on 2026-04-09
138
Participants Needed
4
Research Sites
244 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In patients who has no sign suggesting high lung shunt fraction (TIPS, hepatic vein invasion, hepatic vein enhancement on arterial phase, dysmorphic intratumoral vessel), planning angiography, MAA scan, and radioembolization are performed in a single day with SIR-Spheres. This prospective registry will prove that the selection criteria is accurate and same-day radioembolization is feasible and safe.
CONDITIONS
Official Title
Same-day Radioembolization for Large HCC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with hepatocellular carcinoma confirmed by histology or imaging (LI-RADS 4 or 5)
- Tumor size 5 cm or larger
- Dysmorphic intratumoral vessels 3 mm or smaller
- Child-Pugh class A liver function
- ECOG performance status 0 or 1
- Leukocytes between 1,000 and 20,000 per microliter
- Hemoglobin 6.0 g/dL or higher (transfusion allowed)
- Total bilirubin 2.0 mg/dL or less
- Platelets 40,000 per microliter or higher
- INR 2.0 or less if not taking anticoagulants
- AST 800 IU/L or less
- ALT 800 IU/L or less
- Creatinine 2.5 mg/dL or less (no limit if on hemodialysis)
- Life expectancy more than 3 months
- Able to understand and consent to the clinical trial
- Nonpregnant women of childbearing potential
You will not qualify if you...
- Hepatic vein invasion seen on CT or MRI
- Marked enhancement of portal vein or hepatic vein on arterial phase imaging
- Presence of transjugular intrahepatic portosystemic shunt (TIPS)
- Dysmorphic intratumoral vessels larger than 3 mm
- Main portal vein invasion
- Significant chronic obstructive pulmonary disease (COPD) or interstitial lung disease
- Presence of biliary stent or enterobiliary anastomosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
National Cancer Center
Goyang, South Korea
Actively Recruiting
2
Samsung Medical Center
Seoul, South Korea
Not Yet Recruiting
3
Seoul National University Hospital
Seoul, South Korea
Actively Recruiting
4
Severance hospital
Seoul, South Korea
Not Yet Recruiting
Research Team
H
Hyo-Cheol Kim, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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