Actively Recruiting
Samples From Human Subjects to Facilitate Basic, Translational and Clinical Research
Led by National Institutes of Health Clinical Center (CC) · Updated on 2026-04-24
1000
Participants Needed
1
Research Sites
515 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: This study is designed to provide samples to help us study the genes your blood cells are making as well as the proteins, sugars, fats, vitamins and other metabolites found in your blood or urine. Blood samples may also be collected to make special cells. These are called induced pluripotent stem cells or iPSCs. Pluripotent stem cells are cells that can be converted into any type of cell. Researchers want to study in the lab iPSCs that are derived from blood samples. Objective: To collect samples to help study genes, proteins, sugars, fats, vitamins, and other metabolites found in blood or urine. Eligibility: Healthy volunteers and patients ages 18 and older Design: First-time research study participants at NIH will have an initial visit for this study that should last no more than 1 hour. All other visits should last 20 30 minutes. Participants will undergo a limited history and physical exam. Participants may have routine blood and urine tests. If participants are giving a blood sample, they must have a hemoglobin level checked in the past 12 months to make sure it is safe for them to give a blood sample for research. Participants may have a venous blood collection. They may do this at several visits. They will lie on a recliner or couch or sit in a chair. A needle will be placed into a vein in the hand or arm, using sterile techniques. Blood will be withdrawn into multiple syringes or tubes. Participants may be asked to provide urine in an appropriate container...
CONDITIONS
Official Title
Samples From Human Subjects to Facilitate Basic, Translational and Clinical Research
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- For research subjects with cardiovascular, inflammatory, or endothelial dysfunction diseases: males or females aged 18 or older
- Subjects unable to provide informed consent must have a legally authorized representative
- For subjects receiving continuous renal replacement therapy (CRRT): males or females aged 18 or older
- Healthy volunteers aged 18 or older
- Ability to understand and willingness to sign informed consent
You will not qualify if you...
- Hemoglobin less than 7.0 g/dL
- Receiving infusion of epinephrine or dopamine over 2.5 microgram/kg/min, norepinephrine over 20 mcg/min, or vasopressin over 0.04 units/min
- For known coronary artery disease: systolic blood pressure less than 90 mmHg
- Without known coronary artery disease: systolic blood pressure less than 80 mmHg or mean arterial pressure less than 60 mmHg
- Blood or platelet donation within last 6 weeks (for healthy volunteers)
- Hemoglobin below normal for healthy volunteers (below 11.2 g/dl for females and below 13.7 mg/dl for males)
- History of recreational drug use except marijuana used more than 3 months ago
- Active acute illness such as viral syndrome
- Active tobacco use over 6 months in past 10 years, or any tobacco use within 3 months prior to screening
- History of clinically relevant and active cardiopulmonary disease not well controlled by medications
- For critically ill patients on vasopressors, blood drawn limited to 20 ml in 24 hours and 200 ml over eight weeks
- Any condition deemed by investigators to adversely affect study outcome or volunteer safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
G
Grace M Graninger, R.N.
CONTACT
M
Michael A Solomon, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here