Actively Recruiting
Sarcoma Preoperative Radiation With Simultaneous INTegrated Boost (SPRINT)
Led by Azienda Ospedaliero-Universitaria Careggi · Updated on 2023-03-09
33
Participants Needed
1
Research Sites
258 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Intervention prospective monocentric one arm study on the use of neoadjuvant radiotherapy with simultaneous integrated boost (Simultaneous Integrated Boost, SIB) in patients with STS with indication for preoperative radiotherapy. The treatment will be administered in 25 daily fractions (Monday-Friday) at the disease site to include the region of suspected micrometastatic spread (Clinical Target Volume 1, CTV1) at a dose of 50 Gy (2Gy / fraction) with SIB intensification on volume reduced corresponding to the interface sites between the tumor and the vascular / nerve axes (Clinical Target Volume 2, CTV2) at a dose of 60 Gy (2.4 Gy / fraction). The association with neoadjuvant chemotherapy based on anthracyclines is allowed.
CONDITIONS
Official Title
Sarcoma Preoperative Radiation With Simultaneous INTegrated Boost (SPRINT)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 65 18 years
- Confirmed histological diagnosis of soft tissue sarcoma
- Candidate for conservative surgery
- Performance status 64 1 according to WHO or 65 70 according to Karnofsky Performance Status before treatment start
You will not qualify if you...
- Previous radiotherapy at the same site
- Candidate for surgical amputation
- Comorbidities related to collagen diseases
- Psychiatric disorders that may prevent informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
AOU Careggi
Florence, Fi, Italy, 50134
Actively Recruiting
Research Team
M
Marta Pacinico
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here