Actively Recruiting
Sarcopenia Magnetic Resonance Imaging Evaluation (SUSIE)
Led by The Cleveland Clinic · Updated on 2026-02-11
70
Participants Needed
1
Research Sites
298 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of the proposed research is to investigate Magnetic Resonance (MR) Fingerprinting and P-MRS (Phosphorus-31 MR Spectroscopy) imaging for characterization of skeletal muscle in heart failure patients with sarcopenia. Heart failure patients with and without sarcopenia will be scanned using MR Fingerprinting and an existing Post-exercise phosphocreatine (PCr) recovery MR imaging protocol to obtain characteristic profiles of quantitative T1, T2, and PCr recovery rate.
CONDITIONS
Official Title
Sarcopenia Magnetic Resonance Imaging Evaluation (SUSIE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Heart failure patients aged 40 years or older with stable chronic heart failure and left ventricle ejection fraction 40% or less as determined by cardiac MRI
- Healthy volunteers aged 40 years or older without diagnosed heart failure or sarcopenia
You will not qualify if you...
- Advanced liver disease, advanced cancer, or advanced chronic obstructive pulmonary disease in heart failure patients
- Advanced liver disease, advanced cancer, or advanced chronic obstructive pulmonary disease in healthy volunteers
- Contraindications to MRI
- Presence of heart pacemaker or defibrillator
- Having electronic or implanted stimulators or devices including deep brain stimulator, vagus nerve stimulator, bladder stimulator, spine stimulator, neurostimulators, or implanted electrodes or wires
- Having cochlear implant or other ear implants
- Having implanted drug pumps such as for insulin, narcotic/pain medications, or drugs to treat spasticity
- Having programmable shunt
- Presence of aneurysm clips and coils
- Presence of stents
- Presence of filters such as blood clot filters
- Metal fragments in the body or eye such as BBs, bullets, shrapnel, metal pieces, or shavings
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
Research Team
T
Timothy A Engelman, LPN
CONTACT
W
Wilcox D Wilcox, BA
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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