Actively Recruiting
SBRT for Ventricular Arrhythmia
Led by Medical University of Graz · Updated on 2024-05-13
10
Participants Needed
1
Research Sites
152 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this study is to demonstrate the safety and efficacy of STAR (Stereotactic Antiarrhythmic Radiotherapy) in patients with VT (ventricular tachycardia) who are unresponsive to standard treatments. Additionally, the planned study aims to provide further insights into the effects of STAR on VT burden, ICD interventions, and insights regarding late toxicities, particularly those related to the heart, which are currently not well understood.
CONDITIONS
Official Title
SBRT for Ventricular Arrhythmia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Recurrent ventricular tachycardia with significant burden despite guideline-directed therapy
- Existing protective implantable cardioverter-defibrillator (ICD) implantation unless contraindicated
- Lack of response or intolerance to antiarrhythmic medication
- Status post one or more catheter ablations due to monomorphic VT with early recurrence within 12 months or contraindication for endocardial ablation
- At least 3 VT episodes (sustained VT, ICD-ATP, or ICD shock) in the last 3 months
- Suitable for stereotactic body radiation therapy (SBRT)
- Age 18 years or older
- Provided informed consent
You will not qualify if you...
- Acute myocardial infarction, percutaneous coronary intervention, or heart surgery within 3 months prior to enrollment
- Previous intra-thoracic radiation
- Immediate proximity to radiosensitive structures making therapy unsafe
- Advanced symptomatic heart failure (NYHA Class IV)
- Polymorphic VT or ventricular fibrillation confirmed by ECG or ICD
- Extensive myocardial scar causing too large radiation volume
- Life expectancy less than 6 months
- Presence of a left ventricular assist device (LVAD)
- Use of cytotoxic medications
- Pregnancy or lactation; negative pregnancy test required for women of childbearing potential
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Medical University of Graz
Graz, Austria, 8036
Actively Recruiting
Research Team
T
Tanja Langsenlehner, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here