Study of Hairstyling Methods to Improve Scalp Cooling for Preventing Hair Loss During Chemotherapy in Patients of Color with Breast, Lung, or Gynecologic Cancer

What this Trial Is About

Researchers are studying scalp cooling techniques to reduce hair loss caused by chemotherapy in patients with skin of color who have breast cancer or non-small cell lung cancer. The study focuses on improving scalp cooling effectiveness by using hairstyling methods that reduce hair volume, such as braids, twists, or cornrows, and applying a conditioner and water emulsion to the hair. The study also aims to understand persistent hair loss after chemotherapy and investigate molecular markers that may predict scalp cooling success in these patients. Participants are assigned to one of three groups scalp cooling with a hairstyling method to reduce hair bulk, scalp cooling after coating hair with a conditioner and water mixture, or no scalp cooling. Hair preparation will be done according to the participants preferred method before fitting the cooling cap. The study will follow patients during and after chemotherapy treatment to assess hair preservation and adverse events. Participants will be monitored for hair density and hair loss severity up to six months after completing chemotherapy and for persistent hair loss up to 11 months after treatment ends. Researchers will collect data on patient distress related to hair loss at several time points after chemotherapy. The study includes hair follicle sampling for molecular analysis to explore gene expression changes and biomarkers associated with scalp cooling outcomes. Safety assessments and adverse event monitoring are part of the follow-up process.

Scalp Cooling for Chemotherapy-Induced Alopecia in Patients of Color