Actively Recruiting
The Scottish Aortic Stenosis LongiTudinal Imaging and biomarkeR (SALTIRE) Programme
Led by University of Edinburgh · Updated on 2025-09-17
300
Participants Needed
1
Research Sites
261 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to understand the processes of what causes and accelerates the disease progress in aortic stenosis and following aortic valve replacement. Participants will undergo transthoracic echocardiography every 6 months, with annual visits for state-of-the-art scanning techniques including positron-emission tomography combined with computed tomography or magnetic resonance imaging with radiotracers designed to look at disease processes including fibrosis, calcification, inflammation and thrombosis activity.
CONDITIONS
Official Title
The Scottish Aortic Stenosis LongiTudinal Imaging and biomarkeR (SALTIRE) Programme
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged >50 years
- Provision of informed consent prior to any study specific procedures
- Patients with bioprosthetic aortic valve replacements, including both surgically and transcatheter implanted valves
- Patients with severe aortic stenosis (peak velocity >4.0 m/s; previously recruited patients)
- Patients with moderate aortic stenosis (peak velocity 3.0-4.0 m/s; new prospectively recruited patients)
- Patients with mild aortic stenosis (peak velocity 2.5-2.9 m/s; new prospectively recruited patients)
- Patients with aortic sclerosis (tri-leaflet thickened aortic valve with no obstruction of ventricular outflow)
- Age and sex-matched healthy volunteers
You will not qualify if you...
- Inability or unwillingness to give informed consent
- Allergy to iodinated contrast
- Impaired renal function (eGFR <30 mL/min/1.73m2)
- Women who are pregnant or breastfeeding
- Known Rheumatic Heart Disease
- Known Ochronosis
- Known Familial Homozygous Hypercholesterolaemia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Edinburgh
Edinburgh, United Kingdom, EH16 4SB
Actively Recruiting
Research Team
N
Neil Craig
CONTACT
D
David Newby
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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