Actively Recruiting
Scrambler Therapy for Corticobasal Syndrome-Associated Pain
Led by Johns Hopkins University · Updated on 2026-01-13
25
Participants Needed
1
Research Sites
147 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this pilot trial is to test whether scrambler therapy (ST) is an effective treatment for neuropathic pain in patients with corticobasal syndrome (CBS). The main question it aims to answer is: Will ST reduce pain scores by at least 33% at one month in this pilot trial, justifying further multi-center trials? Participants will: * be randomly assigned treatment from either transcutaneous electrical nerve stimulation (TENS) or ST for pain initially (eventually all patients will receive ST). * have superficial electrocardiogram (ECG) electrodes placed on the dermatomes involved with pain * obtain treatment lasting 30-40 minutes or until pain relief is obtained Researchers will compare patient's response to pain relief with TENS and ST to determine if ST is an effective treatment for central neuropathic pain.
CONDITIONS
Official Title
Scrambler Therapy for Corticobasal Syndrome-Associated Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women aged 50 years or older with corticobasal syndrome
- Average daily pain rating greater than 4 out of 10 on the Brief Pain Inventory
- English speakers or have proficiency in English
- Life expectancy longer than 90 days as assessed by their neurologist
- Able to understand the study requirements, risks, and willing to sign informed consent
You will not qualify if you...
- Pregnant or nursing women, women of childbearing potential or their sexual partners unwilling to use adequate contraception
- Use of an investigational pain control agent currently or within past 30 days
- History of allergic reaction or intolerance to transcutaneous electrical nerve stimulation
- Patients with implantable drug delivery systems like Medtronic Synchromed or baclofen pumps
- Patients with heart stents or metal implants such as pacemakers, defibrillators, cochlear implants, aneurysm clips, vena cava clips, or skull plates (orthopedic implants allowed)
- History of heart attack or ischemic heart disease in past 6 months
- History of epilepsy, brain damage, or symptomatic brain metastases
- Skin conditions like open sores that prevent electrode placement
- Any other medical or health condition that could interfere with study goals as judged by investigators
AI-Screening
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Trial Site Locations
Total: 1 location
1
Johns Hopkins School of Medicine
Baltimore, Maryland, United States, 21205
Actively Recruiting
Research Team
A
Alexander Pantelyat, MD
CONTACT
M
Maria Schmidt, CRNP
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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