Actively Recruiting
Screen CardRen - A Cross-sectional Observational Cohort Study
Led by Charite University, Berlin, Germany · Updated on 2024-08-21
400
Participants Needed
1
Research Sites
69 weeks
Total Duration
On this page
Sponsors
C
Charite University, Berlin, Germany
Lead Sponsor
A
AstraZeneca
Collaborating Sponsor
AI-Summary
What this Trial Is About
In this single-centre, cross-sectional study, the investigators aim to assess the prevalence of asymptomatic echocardiographic structural and functional cardiac abnormalities in adult CKD patients with additional cardiovascular risk factors. Furthermore, with the use of Olink technology, analyses of the plasma proteome will be performed to identify potential protein pathways associated with early structural changes.The investigators hypothesize that protein expression will be altered in patients with prevalent echocardiographic abnormalities that indicate stage B heart failure.
CONDITIONS
Official Title
Screen CardRen - A Cross-sectional Observational Cohort Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Chronic Kidney Disease stages G1-G4
- Estimated glomerular filtration rate (eGFR) 60 ml/min/1.73m8 with urine albumin-to-creatinine ratio 30 mg/g (3 mg/mmol) OR eGFR between 15 and 60 ml/min/1.73m8
- Diagnosis of type 2 diabetes mellitus OR abnormal oral glucose tolerance test (200 mg/dl at 2 hours) OR HbA1c 6.5% OR use of antidiabetic medication OR fasting blood glucose 126 mg/dl
- Arterial hypertension grade 1 OR blood pressure 140/90 mmHg OR use of antihypertensive drugs
- Hypercholesterolemia OR LDL-cholesterol above 130 mg/dl OR use of lipid-lowering medication for dyslipoproteinemia
You will not qualify if you...
- History of acute kidney injury worse than stage 1 in the two weeks before study visit
- Chronic kidney disease stage 5 (end-stage renal disease)
- Previous diagnosis of chronic heart failure
- Acute myocardial infarction in the past 30 days
- Stroke in the past 30 days
- Known congenital heart disease
- Previous diagnosis of specific cardiomyopathy, infiltrative cardiac disease, pericardial constriction, sarcoidosis, amyloidosis, or other storage diseases
- Implanted cardiac devices such as pacemakers, implantable cardioverter-defibrillators, or resynchronization devices
- Implanted mechanical heart valve prosthesis
- Inability to give informed consent
- Lack of health insurance
- Organ transplant recipient
- Use of immunosuppressive medication
- Major surgery in the past 6 months, including cardiac bypass or valve replacement, major vascular surgery, major abdominal surgery, or limb amputation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
German Heart Center Charité (DHZC)
Wedding, State of Berlin, Germany, 13353
Actively Recruiting
Research Team
D
Daniela Zurkan
CONTACT
F
Friederike Fenske
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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