Actively Recruiting
Screening for AL Amyloidosis in Smoldering Multiple Myeloma
Led by Tufts Medical Center · Updated on 2025-08-06
400
Participants Needed
13
Research Sites
251 weeks
Total Duration
On this page
Sponsors
T
Tufts Medical Center
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
In this multicenter study, we will recruit 400 patients 40 years of age or older at 15 centers with a diagnosis of smoldering multiple myeloma (SMM), a group of patients for whom standard of care is observation not treatment. The main goal of this study is to screen for the diagnosis of light-chain amyloidosis (AL) before the onset of symptomatic disease and to develop a training set for a likelihood algorithm.
CONDITIONS
Official Title
Screening for AL Amyloidosis in Smoldering Multiple Myeloma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 40 years of age and older
- Diagnosed with either Smoldering Multiple Myeloma or a Monoclonal Gammopathy
- dFLC greater than 23 mg/L
- Abnormal FLC ratio
- If eGFR is less than 50 mL/min/1.73m2, FLC ratio is not considered; must meet age and dFLC criteria
You will not qualify if you...
- Patients younger than 40 years of age
- Previous finding of amyloid in other biopsies
- Adults unable to consent, including cognitively impaired
- Pregnant women and pregnant minors
- Minors (individuals who are not adults)
- Wards of the state
- Non-viable neonates or neonates of uncertain viability
- Prisoners
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 13 locations
1
University of Alabama Hospital
Birmingham, Alabama, United States, 35233
Actively Recruiting
2
Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
3
University of California, San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
4
Cleveland Clinic Florida, Weston Hospital
Weston, Florida, United States, 33331
Actively Recruiting
5
Tufts Medical Center
Boston, Massachusetts, United States, 02111
Actively Recruiting
6
Columbia University Irving Medical Center
New York, New York, United States, 10032
Actively Recruiting
7
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
8
Atrium Health Levine Cancer Institute
Charlotte, North Carolina, United States, 28204
Actively Recruiting
9
UNC Lineberger Comprehensive Cancer Center
Durham, North Carolina, United States, 27705
Actively Recruiting
10
The Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States, 43210
Actively Recruiting
11
UT Southwestern, Harold C. Simmons Comprehensive Cancer Center
Dallas, Texas, United States, 75390
Not Yet Recruiting
12
University of Utah, Huntsman Cancer Hospital
Salt Lake City, Utah, United States, 84112
Actively Recruiting
13
VCU Medical Center
Richmond, Virginia, United States, 23219
Actively Recruiting
Research Team
R
Raymond Comenzo, MD
CONTACT
D
Denis Toskic, BS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here