Actively Recruiting
Screening for Anal Cancer in Men Who Have Sex With Men Using Pre-Exposure Prophylaxis
Led by Universitair Ziekenhuis Brussel · Updated on 2026-05-01
296
Participants Needed
8
Research Sites
62 weeks
Total Duration
On this page
Sponsors
U
Universitair Ziekenhuis Brussel
Lead Sponsor
A
A.M.L.
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to learn more about anal cancer risk in men who have sex with men (MSM) who are using Pre-Exposure Prophylaxis (PrEP) to prevent HIV. Specifically, we want to check how common High-Grade Squamous Intraepithelial Lesions (HSIL) are in this group, how well anal swabs can screen for these lesions, and how having HSIL affects their quality of life. We'll also test if DNA methylation testing can give us extra information about the lesions. The main questions the study aims to answer are: * How common are HSIL in MSM using PrEP? * How accurate are anal swabs for detecting HSIL in this group? * How does having HSIL affect the quality of life of MSM using PrEP? * Can DNA methylation testing help improve our understanding of HSIL in these individuals? Participants will: * Answer questions about their health and quality of life. * Have an anal smear collected for testing. * Undergo High-Resolution Anoscopy (HRA) to check for HSIL and get a biopsy if deemed necessary.
CONDITIONS
Official Title
Screening for Anal Cancer in Men Who Have Sex With Men Using Pre-Exposure Prophylaxis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- HIV-uninfected men who have sex with men aged 35 years or older
- Using PrEP for at least 3 months
- Able to speak and write Dutch, English, or French
You will not qualify if you...
- Any intervention in the anal or peri-anal region within the past 3 months
- Use of enema within 2 hours before sampling
- Currently receiving peri-anal topical HPV treatment
- Had High-Resolution Anoscopy (HRA) within the last year
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
AZ Sint Jan
Bruges, Belgium, 8000
Active, Not Recruiting
2
CHU Saint-Pierre
Brussels, Belgium, 1000
Actively Recruiting
3
Cliniques universitaires Saint-Luc - UCLouvain
Brussels, Belgium, 1200
Actively Recruiting
4
UZ Brussel
Brussels, Belgium
Actively Recruiting
5
UZ Gent
Ghent, Belgium, 9000
Actively Recruiting
6
Jessaziekenhuis
Hasselt, Belgium
Actively Recruiting
7
UZ Leuven
Leuven, Belgium, 3000
Active, Not Recruiting
8
CHU Charleroi - Chimay
Lodelinsart, Belgium, 6042
Actively Recruiting
Research Team
M
Magali Surmont
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SCREENING
Number of Arms
1
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