Actively Recruiting
Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates
Led by University of British Columbia · Updated on 2024-05-13
3306
Participants Needed
22
Research Sites
369 weeks
Total Duration
On this page
Sponsors
U
University of British Columbia
Lead Sponsor
U
University of Sydney
Collaborating Sponsor
AI-Summary
What this Trial Is About
The Canadian Australasian Randomized Trial of Screening Kidney Transplant Candidates for Coronary Artery Disease (CARSK) will test the hypothesis that eliminating the regular use of non-invasive screening tests for CAD AFTER waitlist activation is not inferior to regular (i.e., annual) screening for CAD during wait-listing for the prevention of Major Adverse Cardiac Events. Secondary analyses will assess the impact of screening on the rate of transplantation, and the relative cost-effectiveness of screening.
CONDITIONS
Official Title
Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years of age or older
- Dialysis-dependent kidney failure and currently being assessed for OR active on the kidney transplant waiting list
- Expected to require further screening for coronary artery disease before transplantation by current standard of care
- Able to give consent
- Anticipated to undergo transplantation more than 12 months from date of enrolment
You will not qualify if you...
- Signs or symptoms of uncontrolled cardiac disease such as unstable coronary syndromes, decompensated heart failure, uncontrolled arrhythmia, and severe valvular heart disease
- Patients who are "on-hold" for transplantation due to a medical problem
- Patients with other solid organ transplants
- Multi-organ transplant candidates (e.g., kidney-pancreas transplant candidates)
- Patients with planned living donor transplant
- Patients unable to give consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 22 locations
1
University of Arizona
Tucson, Arizona, United States, 85724
Actively Recruiting
2
The George Washington University
Washington D.C., District of Columbia, United States, 20052
Actively Recruiting
3
University of Alberta
Edmonton, Alberta, Canada
Actively Recruiting
4
University of British Columbia
Vancouver, British Columbia, Canada, V6Z 1Y6
Actively Recruiting
5
Dalhousie University
Halifax, Nova Scotia, Canada, B3H 1V8
Actively Recruiting
6
St. Joseph's Healthcare
Hamilton, Ontario, Canada, L8N 4A6
Actively Recruiting
7
Kingston Health Science Centre
Kingston, Ontario, Canada
Actively Recruiting
8
London Health Science Centre
London, Ontario, Canada
Actively Recruiting
9
The Ottawa Hospital Research Institute
Ottawa, Ontario, Canada, K1H 7W9
Actively Recruiting
10
University Health Network
Toronto, Ontario, Canada, M5G 2N2
Actively Recruiting
11
St Michael's Hospital
Toronto, Ontario, Canada
Actively Recruiting
12
CHU de Quebec-Universite Laval's L'Hotel-Dieu de Quebec
Laval, Quebec, Canada
Actively Recruiting
13
University of Montreal, Maisonneuve-Rosemont Hospital
Montreal, Quebec, Canada, H1T 2M4
Actively Recruiting
14
McGill University Health Centre
Montreal, Quebec, Canada
Actively Recruiting
15
Universite de Montreal, Hopital Maisonneuve-Rosemont
Montreal, Quebec, Canada
Actively Recruiting
16
St. Paul's Hospital, University of Saskatchewan
Saskatoon, Saskatchewan, Canada
Actively Recruiting
17
Charité Universitätsmedizin
Berlin, Germany
Not Yet Recruiting
18
Sussex Brighton R&D
Brighton, United Kingdom, BN2 1ES
Actively Recruiting
19
King's College Hospital NHS Foundation Trust
Brixton, United Kingdom, SW9 8RR
Actively Recruiting
20
Epsom and St Helier University Hospitals NHS Trust
Carshalton, United Kingdom, SM5 1AA
Actively Recruiting
21
Barts Health NHS Trust
London, United Kingdom, E1 4UJ
Actively Recruiting
22
St George's University Hospital NHS Trust Foundation
London, United Kingdom
Not Yet Recruiting
Research Team
B
Breanna Riou-Green
CONTACT
G
Gurvir Thind
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SCREENING
Number of Arms
2
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