Actively Recruiting
Screening of Biomarkers for Osteoarthritis and Establishment of a Multidimensional Data Based Early Diagnostic Method
Led by The First Affiliated Hospital of Xinxiang Medical College · Updated on 2026-04-22
300
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Osteoarthritis (OA) is the most common degenerative joint disease worldwide, especially affecting people over 60 years old. In China, OA cases are rising rapidly due to aging and lifestyle changes, with projections exceeding 200 million patients by 2044. This research aims to find reliable biomarkers for early diagnosis to improve prevention, diagnosis, and personalized treatment of OA, focusing on patients with early-stage disease and those with similar symptoms prone to misdiagnosis. The study will collect blood samples from patients with OA, mainly targeting joints like the knee, hip, and hand. Participants include early-stage OA patients with specific imaging grades and those suspected of having OA. Diagnostic tests will verify previously reported candidate biomarkers, helping to identify those with strong clinical value. This observational study does not involve treatment but focuses on gathering clinical, imaging, and biological data to develop early diagnostic methods. Participants will undergo diagnostic evaluations at enrollment and provide blood samples for biomarker screening about 100 days later. Researchers will assess joint pain, stiffness, imaging results, and other clinical features. Follow-up visits and examinations like X-rays and MRIs are part of the study. The goal is to analyze data to support early detection and individualized care for OA, with a study duration extending until the end of 2026.
CONDITIONS
Brief Title
Screening for Biomarkers of Osteoarthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged between 40 and 70 years (inclusive)
- Joint pain or stiffness lasting for no less than 3 months
- Voluntary participation with signed informed consent
You will not qualify if you...
- Combined with other severe joint diseases, such as rheumatoid arthritis, gout, etc.
- Suffering from severe systemic diseases, such as heart failure, malignant tumors and others
- Received joint surgery within the past 3 months or taking medications that may affect the progression of osteoarthritis
- Individuals with cognitive dysfunction who are unable to cooperate with the research procedures
- Failure to complete X-ray, MRI examination or follow-up visits as required
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 100 days
Participants undergo diagnostic assessments to identify osteoarthritis and collect clinical data and biological samples.
Visits as needed for sample collection and imaging assessments
Duration - Up to study completion
Participants are monitored over time to observe disease progression and biomarker changes.
Follow-up visits as required
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Henan Medical University
Xinxiang, Henan, China, 453003
Actively Recruiting
Research Team
W
Wenjie Ren
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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