Actively Recruiting
Screening for Biomarkers of Osteonecrosis of the Femoral Head
Led by The First Affiliated Hospital of Xinxiang Medical College · Updated on 2026-04-22
300
Participants Needed
1
Research Sites
57 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Osteonecrosis of the femoral head (ONFH) presents a rapidly progressive natural disease course. Femoral head collapse may occur within two years, ultimately necessitating total hip arthroplasty and imposing a heavy medical and economic burden on patients. Early intervention can significantly improve the long-term prognosis of ONFH. However, due to the lack of validated biomarkers for early diagnosis, the early diagnostic rate remains low, with a primary diagnostic rate of merely 68.43% at the first visit, accompanied by a high rate of misdiagnosis. This project intends to collect blood samples from patients diagnosed with ONFH and suspected cases in the orthopedic outpatient department of a tertiary Grade A hospital. Diagnostic and differential diagnostic tests will be adopted to evaluate the clinical application value of previously reported candidate biomarkers, so as to screen out biomarkers with excellent diagnostic validity and reliability. Meanwhile, clinical data will be collected to identify independent risk factors, and a multi-dimensional integrated diagnostic model will be further established. The research findings are expected to provide solid data support, theoretical basis and technical reserves for the early prevention, early diagnosis and individualized intervention of osteonecrosis of the femoral head.
CONDITIONS
Official Title
Screening for Biomarkers of Osteonecrosis of the Femoral Head
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged between 18 and 70 years old (inclusive).
- Patients with suspected osteonecrosis of the femoral head (ONFH).
- Willing to provide informed consent and volunteer to participate in the study.
You will not qualify if you...
- History of hip trauma.
- Osteonecrosis secondary to traumatic causes such as femoral neck fracture or hip dislocation.
- Severe mental illness or cognitive impairment preventing questionnaire completion.
- Refusal to sign the informed consent form.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The First Affiliated Hospiatl of Henan Medical University
Xinxiang, Henan, China, 453003
Actively Recruiting
Research Team
W
Wenjie Ren
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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