Actively Recruiting
Screening and Follow-up in Patients With HIV Infection Combined With Metabolic Associated Fatty Liver Disease
Led by Peking Union Medical College Hospital · Updated on 2025-12-09
200
Participants Needed
1
Research Sites
369 weeks
Total Duration
On this page
Sponsors
P
Peking Union Medical College Hospital
Lead Sponsor
W
Wuxi Hisky Medical Technology Co Ltd
Collaborating Sponsor
AI-Summary
What this Trial Is About
Identifying patients at risk of NAFLD(Nonalcoholic fatty liver disease), especially severe disease with NASH(nonalcoholic steatohepatitis) and fibrosis, is critical. Prevalence of NAFLD in PLWH(People Living With HIV) evaluated by different imaging techniques including US (ultrasonography), elastography, CT(computed tomography ), and magnetic resonance varies from 13% to 58.6% in all published studies. In previous studies, the effect of ART(Anti-Retroviral Therapy) on NAFLD was limited. A cross-sectional analysis found that INSTI（Integrase strand transfer inhibitor） was associated with a higher prevalence of steatosis in AIDS (acquired immunodeficiency syndrome) patients. However, it is not clear whether there is a difference in the degree of nonalcoholic steatosis between AIDS patients receiving NNRTI(non-nucleoside reverse transcriptase inhibitors). Therefore, the investigators plan to conduct a prospective study to assess whether there is any difference in the degree of nonalcoholic steatosis and fibrosis between Chinese HIV(human immunodeficiency virus)/AIDS patients after initial treatment with NNRTI or INSTI, or switching from NNRTI to INSTI.
CONDITIONS
Official Title
Screening and Follow-up in Patients With HIV Infection Combined With Metabolic Associated Fatty Liver Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Newly treated or treated AIDS patients
- Regular follow-up visits to the hospital with good medication compliance
- Patients or their family members willing to participate and able to provide written informed consent
You will not qualify if you...
- Unable to lie flat for ultrasound examination due to mobility difficulties
- Poor compliance with follow-up visits or medication schedule
- Patients or family members unable to understand the study conditions and objectives
- Other conditions deemed unsuitable for participation by the investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Chinese Academy of Medical Sciences Peking Union Medical College Hospital
Beijing, Beijing Municipality, China, 100020
Actively Recruiting
Research Team
Q
QING ZHANG
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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