Finding the Best Screening Method to Prevent Gastric Cancer by Detecting H. pylori Infection in Adults

What this Trial Is About

Researchers are conducting a prospective, randomized trial to find the best way to screen for H. pylori infection to help prevent gastric cancer. The study compares different screening methods to understand which tests are most acceptable, accurate, and followed well by adults aged 20 years and older who have not previously been screened or treated for H. pylori infection. Participants are randomly placed into groups receiving one of four diagnostic test methods the carbon-13 urea breath test UBT, the H. pylori stool antigen test HpSA, a standard method combining both UBT and HpSA, or a two-stage screening starting with serology followed by confirmation with UBT if positive. Enrollment for the HpSA and two-stage groups has been stopped after initial analysis, and the study continues enrolling participants for the UBT and standard method groups to reach their target numbers. During the study, participants will undergo these screening tests with follow-up assessments over a period from 2 weeks up to 1 year to measure detection rates of H. pylori infection and adherence to the screening. Researchers will monitor compliance and diagnostic accuracy, and assess the potential long-term impact on reducing gastric cancer risk. The study participation duration and testing schedules are designed to collect detailed data on test performance and acceptability.

Screening Strategy for Gastric Cancer Prevention