Actively Recruiting
Screening for Synchronous Metastases in Colorectal Cancer With DW-MRI (SERENADE)
Led by Imperial College London · Updated on 2024-10-17
282
Participants Needed
13
Research Sites
904 weeks
Total Duration
On this page
Sponsors
I
Imperial College London
Lead Sponsor
P
Pelican Cancer Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Eligible patients with high risk colorectal malignancy (T3/4, spread greater than 5mm, EMVI positive) will have additional surveillance of breath hold T1, T2 and DW-MRIs (no IV contrast) post surgery six monthly for three years. Findings of liver MRIs as reported by radiology PI will be shared with their local MDT who make decisions as appropriate, including the management of any identified liver metastases, according to local protocol.
CONDITIONS
Official Title
Screening for Synchronous Metastases in Colorectal Cancer With DW-MRI (SERENADE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a high risk primary colorectal malignancy
- Have a negative CT or no confirmatory evidence of liver metastases
- Are able to undergo treatment if liver metastasis is found
- Have provided written informed consent to participate in the study
- Be aged 16 years or over
You will not qualify if you...
- Have had a previous colorectal malignancy
- Have metastatic disease
- Have a synchronous second malignancy
- Are contraindicated for MRI
- Have a T3b or below low rectal tumour without EMVI or N1c
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 13 locations
1
Macclesfield District General Hospital
Macclesfield, Cheshire, United Kingdom, SK10 3BL
Actively Recruiting
2
Queen's Hospital
Burton-on-Trent, Derbyshire, United Kingdom, DE13 0RB
Not Yet Recruiting
3
Broomfield Hospital
Chelmsford, Essex, United Kingdom, CM1 7ET
Actively Recruiting
4
Royal Bolton Hospital
Bolton, Greater Manchester, United Kingdom, BL4 0JR
Actively Recruiting
5
Medway Maritime Hospital
Gillingham, Kent, United Kingdom, ME7 5NY
Actively Recruiting
6
University Hospital of South Manchester & Manchester Royal Infirmary
Wythenshawe, Manchester, United Kingdom, M23 9LT
Actively Recruiting
7
Royal Liverpool Hospital
Liverpool, Merseyside, United Kingdom, L7 8XP
Actively Recruiting
8
Royal Stoke University Hospital
Stoke-on-Trent, Staffordshire, United Kingdom, ST4 6QG
Actively Recruiting
9
Royal Marsden Hospital
Sutton, Surrey, United Kingdom, SM2 5PT
Actively Recruiting
10
Royal Gwent Hospital
Newport, Wales, United Kingdom, NP20 2UB
Actively Recruiting
11
George Eliot Hospital
Nuneaton, Warwickshire, United Kingdom, CV10 7DJ
Actively Recruiting
12
Salisbury District Hospital
Salisbury, Wiltshire, United Kingdom, SP2 8BJ
Actively Recruiting
13
Queen Alexandra Hospital
Portsmouth, United Kingdom
Actively Recruiting
Research Team
C
Caroline Martin
CONTACT
S
Syvella Ellis
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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