Actively Recruiting
Searching for Novel Therapeutic Approaches in Migraine Patients Resistant to Treatments
Led by IRCCS National Neurological Institute "C. Mondino" Foundation · Updated on 2024-08-20
45
Participants Needed
1
Research Sites
155 weeks
Total Duration
On this page
Sponsors
I
IRCCS National Neurological Institute "C. Mondino" Foundation
Lead Sponsor
U
University of L'Aquila
Collaborating Sponsor
AI-Summary
What this Trial Is About
Primary working hypothesis is that NON-responders to mAbs bear a dysfunction of the endocannabidiome system (eCBome), as suggested by pre-clinical and clinical data by our group. They will be identified as patients showing a reduction of monthly migraine days \< 50% after three months of treatment. The clinical, biochemical and neurofunctional impact of novel therapeutic approaches expected to interfere with eCBome will be evaluated in NON-responder patients
CONDITIONS
Official Title
Searching for Novel Therapeutic Approaches in Migraine Patients Resistant to Treatments
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female patients aged 18 to 75 years
- Diagnosis of episodic or chronic migraine according to ICHD-3 criteria
- For episodic migraine: 8-14 monthly migraine days in the previous 3 months
- Diagnosis of resistant migraine, defined by failure of at least 3 classes of migraine preventatives and at least 8 disabling monthly headache days for 3 consecutive months
- Patients who have not previously received CGRP targeting treatments
You will not qualify if you...
- History of major psychiatric or other neurological conditions
- Diagnosis of other primary or secondary headache disorders except sporadic tension-type headache if distinguishable
- Clinically significant medical conditions
- Chronic pain conditions
- Alcohol or drug abuse
- Pregnancy or lactation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Headache Science & Neurorehabilitation Unit
Pavia, Italy, 27100
Actively Recruiting
Research Team
R
Roberto De Icco
CONTACT
C
Cinzia Fattore
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here