Actively Recruiting
Second or Greater Allogeneic Hematopoietic Stem Cell Transplant Using Reduced Intensity Conditioning (RIC)
Led by Masonic Cancer Center, University of Minnesota · Updated on 2025-07-24
30
Participants Needed
1
Research Sites
773 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a treatment guideline for a second or greater allogeneic hematopoietic stem cell transplant (HSCT) using a reduced intensity conditioning (RIC) in patients with non-malignant or malignant diseases. This regimen, consisting of busulfan, fludarabine, and low dose total body irradiation (TBI), is designed to promote engraftment in patients who failed to achieve an acceptable level of donor-derived engraftment following a previous allogeneic HCT.
CONDITIONS
Official Title
Second or Greater Allogeneic Hematopoietic Stem Cell Transplant Using Reduced Intensity Conditioning (RIC)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis requiring a second or greater hematopoietic stem cell transplant due to insufficient donor chimerism after prior transplant
- Sufficient donor graft available based on transplant center criteria, including matched related or unrelated donors, peripheral blood or bone marrow grafts, and eligible cord blood grafts
- Age between 0 and 55 years
- Voluntary written consent from adult or parent/guardian
You will not qualify if you...
- Previous radiation therapy that prevents safe administration of an additional 200 cGy total body irradiation
- Pregnant or breastfeeding
- Active uncontrolled infection not stable or improving after appropriate therapy
- HIV positive
- Timing since prior transplant regimen less than recommended but with recognized exceptions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Masonic Cancer Center, University of Minnesota
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
Research Team
T
Troy Lund, M.D., Ph.D.
CONTACT
P
Paul Orchard, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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