Actively Recruiting
Secondary Interval Cytoreductive Surgery in Platinum-sensitive Recurrent Epithelial Ovarian Cancer
Led by The University of Hong Kong · Updated on 2025-06-11
18
Participants Needed
1
Research Sites
165 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
About 80% of advanced ovarian cancer patients recurred in 2-3 years. Secondary cytoreduction benefits selected patients who have high chance of complete resection. Whether secondary interval surgery can be used at recurrence is not known.
CONDITIONS
Official Title
Secondary Interval Cytoreductive Surgery in Platinum-sensitive Recurrent Epithelial Ovarian Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically diagnosed epithelial ovarian cancer, fallopian tube, or primary peritoneal carcinoma
- Completed 3 or more cycles of platinum-based chemotherapy, with or without bevacizumab and/or PARPi, as initial treatment
- Platinum-free interval of 6 months or longer since last platinum chemotherapy
- Upfront secondary cytoreductive surgery not feasible
- Eastern Cooperative Oncology Group (ECOG) performance score between 0 and 2 within 28 days before recruitment
- Adequate bone marrow, kidney, liver, and neurological function within 28 days before starting treatment
You will not qualify if you...
- Non-epithelial or borderline tumors
- Concurrent malignancy within five years, except basal or squamous cell skin cancer, in-situ breast cancer, or early-stage endometrial carcinoma without lymphovascular invasion
- More than one line of chemotherapy received
- Platinum-resistant or refractory recurrence
- Second or later relapse
- Contraindications to surgery, including unresolved low platelet count or bowel obstruction within 4 weeks before enrollment
AI-Screening
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Trial Site Locations
Total: 1 location
1
The University of Hong Kong
Hong Kong, Hong Kong
Actively Recruiting
Research Team
L
Lesley Lau
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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