Actively Recruiting
Sedation, Temperature and Pressure After Cardiac Arrest and Resuscitation
Led by Region Skane · Updated on 2025-07-15
3500
Participants Needed
56
Research Sites
171 weeks
Total Duration
On this page
Sponsors
R
Region Skane
Lead Sponsor
L
Lund University, Lund, Sweden
Collaborating Sponsor
AI-Summary
What this Trial Is About
The STEPCARE-trial is a 2x2x2 randomised trial studying patients who have been resuscitated from cardiac arrest and who are comatose. It will include three different interventions focusing on sedation targets, temperature targets and mean arterial pressure targets.
CONDITIONS
Official Title
Sedation, Temperature and Pressure After Cardiac Arrest and Resuscitation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Out-of-hospital cardiac arrest
- Sustained return of spontaneous circulation (ROSC) for at least 20 minutes without chest compressions
- Unconsciousness defined as inability to obey verbal commands or being intubated and sedated due to agitation after ROSC
- Eligible for intensive care without restrictions or limitations
- Enrollment within 4 hours of ROSC
You will not qualify if you...
- Receiving ECMO before randomization
- Pregnancy
- Suspected or confirmed intracranial hemorrhage
- Previously enrolled in the STEPCARE trial
- Cardiac arrest caused by trauma or hemorrhage
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 56 locations
1
Nepean Hospital
Kingswood, New South Wales, Australia
Actively Recruiting
2
Liverpool Hospital
Liverpool, New South Wales, Australia
Actively Recruiting
3
Royal North Shore Hospital
Sydney, New South Wales, Australia
Actively Recruiting
4
St George Hospital
Sydney, New South Wales, Australia
Actively Recruiting
5
The Sutherland Hospital
Sydney, New South Wales, Australia
Actively Recruiting
6
Princess Alexandra Hospital
Brisbane, Queensland, Australia
Actively Recruiting
7
The Prince Charles Hospital
Brisbane, Queensland, Australia
Actively Recruiting
8
Austin Hospital
Melbourne, Victoria, Australia
Actively Recruiting
9
HUB Hôpital Erasme
Brussels, Belgium, 1077
Actively Recruiting
10
Ghent University Hospital
Ghent, Belgium, 9000
Actively Recruiting
11
Ziekenhuis Oost-Limburg Hospital
Lanaken, Belgium, 3620
Actively Recruiting
12
North Estonia Medical Centre, Tallinn
Tallinn, Estonia, 13409
Actively Recruiting
13
Jorvi Hospital
Espoo, Finland
Actively Recruiting
14
Meilahti Hospital
Helsinki, Finland, 00290
Actively Recruiting
15
Helsinki Helsingforgs University Central Hospital
Helsinki, Finland
Actively Recruiting
16
Jyväskylä Hospital
Jyväskylä, Finland
Actively Recruiting
17
Kuopio University Hospital
Kuopio, Finland
Actively Recruiting
18
Oulu University Hospital
Oulu, Finland
Actively Recruiting
19
Tampere University Hospital
Tampere, Finland
Actively Recruiting
20
Charite University Hospital
Berlin, Germany
Actively Recruiting
21
Lübeck University Hospital
Lübeck, Germany
Actively Recruiting
22
Tubingen University Hospital
Tübingen, Germany
Actively Recruiting
23
St Vincents University Hospital
Dublin, Ireland
Active, Not Recruiting
24
San Martino Hospital Genova
Genova, Italy
Actively Recruiting
25
Centre Hospitalier de Luxembourg
Luxembourg, Luxembourg
Actively Recruiting
26
DCCM ICU
Auckland, New Zealand
Actively Recruiting
27
Middlemore ICU
Auckland, New Zealand
Actively Recruiting
28
North Shore ICU NZ
Auckland, New Zealand
Actively Recruiting
29
Christchurch Hospital
Christchurch, New Zealand
Actively Recruiting
30
Whangarei ICU
Northland, New Zealand
Active, Not Recruiting
31
Wellington Hospital
Wellington, New Zealand
Actively Recruiting
32
Soerlandet Hospital Arendal
Arendal, Norway
Actively Recruiting
33
Kalnes Hospital
Kalnes, Norway
Actively Recruiting
34
Oslo University Hospital
Oslo, Norway
Actively Recruiting
35
Stavanger University Hospital
Stavanger, Norway
Actively Recruiting
36
King Abdulaziz Medical City
Riyadh, Saudi Arabia
Actively Recruiting
37
Tan Tock Seng Hospital
Singapore, Singapore
Actively Recruiting
38
Hallands hospital
Halmstad, Halland County, Sweden
Actively Recruiting
39
Helsingborg Hospital
Helsingborg, Skåne County, Sweden
Actively Recruiting
40
Skåne University Hospital
Lund, Skåne County, Sweden
Actively Recruiting
41
Skåne University Hospital Malmö
Malmö, Skåne County, Sweden
Actively Recruiting
42
Sahlgrenska University Hospital
Gothenburg, Sweden
Actively Recruiting
43
Karlstad hospital
Karlstad, Sweden
Actively Recruiting
44
Skaraborg Hospital Skovde
Skövde, Sweden
Actively Recruiting
45
Karolinska University Hospital
Stockholm, Sweden
Actively Recruiting
46
University Hospital of Umeå
Umeå, Sweden
Actively Recruiting
47
Bern University Hospital
Bern, Switzerland
Actively Recruiting
48
St Gallen Hospital
Sankt Gallen, Switzerland
Actively Recruiting
49
University Hospital Zürich
Zurich, Switzerland
Actively Recruiting
50
Essex Cardiothoracic Centre
Basildon, United Kingdom
Actively Recruiting
51
Bristol Royal Infirmary
Bristol, United Kingdom
Actively Recruiting
52
Cardiff University Hospital
Cardiff, United Kingdom
Actively Recruiting
53
Leeds General Infirmary
Leeds, United Kingdom
Actively Recruiting
54
Kings College Hospital
London, United Kingdom
Actively Recruiting
55
St Bartholomew's Hospital
London, United Kingdom
Actively Recruiting
56
St Georges University Hospital
London, United Kingdom
Actively Recruiting
Research Team
J
Josef Dankiewicz, PhD
CONTACT
N
Niklas Nielsen, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
8
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