Actively Recruiting
Sedentary or Exercised : Neuromuscular and Immunometabolic Observations and Retrospection
Led by Centre Hospitalier Universitaire de Nice · Updated on 2025-04-17
40
Participants Needed
1
Research Sites
85 weeks
Total Duration
On this page
Sponsors
C
Centre Hospitalier Universitaire de Nice
Lead Sponsor
L
LAMHESS
Collaborating Sponsor
AI-Summary
What this Trial Is About
The distinction between healthy and pathological ageing has given rise to the vitality capacity concept. Underlying the physiological aspect of ageing, vitality capacity is reflected in the neuromuscular function, metabolism, and immune and stress response. The three domains seem to deteriorate with age, except among individuals who have maintained physical activity throughout their lives. Furthermore, immune cells, particularly T lymphocytes, appear to play a key role in each dimension of vitality capacity, as well as in the mice ageing pathway. Investigators sought to determine the effect of lifelong physical activity on vitality capacity, and especially on T cell metabolism. In this optic, fourty healthy participants over the age of 55 will be allocated to two groups: 20 who have maintained physical activity for the past 30 years, and 20 who have not. Each participant's vitality capacity will be deeply tested and compared to their physical activity background.
CONDITIONS
Official Title
Sedentary or Exercised : Neuromuscular and Immunometabolic Observations and Retrospection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women over 55 years old
- Non-smokers or those who quit smoking more than 3 years ago
- Menopausal women for at least 6 months
- Affiliated to the social security system
- Signed informed consent
- Active group: structured aerobic physical activity on at least 3 days/week for the last 30 years with minimal interruptions
- Active group: physical activity meeting WHO recommendations for duration and intensity (150-300 min moderate or 75-150 min sustained intensity per week)
- Inactive group: do not meet active group criteria
- Inactive group: low-intensity professional activity over last 30 years (sedentary or standing without intense effort)
- Inactive group: no or very limited sport, fitness, or physical leisure activities (less than or equal to 2 days/week and under 75 minutes total weekly)
- Inactive group: active transport (walking, cycling) less than 75 min per week with trips under 10 minutes each
You will not qualify if you...
- Chronic illness
- Use of performance-enhancing drugs
- Disability
- Medication use
- Hospitalization within last 6 months
- Osteoarthritis
- Cardiovascular events in last 30 years (angina, heart attack)
- Current acute inflammatory condition
- History of sports-related vascular complications
- Under guardianship or trusteeship
- Withdrawal of consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
CHU de Nice
Nice, France, 06000
Actively Recruiting
Research Team
A
Anne-Sophie Rousseau, PU
CONTACT
F
Frederic CHORIN, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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