Study of Home Exercise Benefits and Health Outcomes in Adults Over 40 with Advanced Chronic Kidney Disease

What this Trial Is About

Researchers are investigating whether a simple home exercise program can help people with advanced chronic kidney disease CKD. The study also includes an observational part without any exercise program to understand the links between cardiovascular and kidney health, exercise ability, and negative health outcomes. The study focuses on patients over 40 years old who have severe kidney impairment and are at high risk for death, heart problems, hospital visits, and bone fractures. Participants in the study are randomly assigned to either receive education from a physiotherapist on how to perform physical training and exercise regularly at home at least three times a week, or to continue with their usual care without the exercise program. The study tracks outcomes over several years, with a focus on hospitalizations, mortality, major cardiovascular or cerebrovascular events, emergency visits, walking distance, kidney replacement therapy, and compliance with the exercise program. During the study, researchers will collect data on physical tests like the six-minute walk and maximal oxygen uptake, quality of life, bone fractures, blood tests, and X-rays. These measurements will occur at multiple time points up to the end of 2031. The study aims to understand how frailty and physical and psychological capabilities relate to health events and treatment outcomes in patients with advanced CKD.

SEDentary Lifestyle, Mortality and Major Adverse Clinical Outcomes in Chronic KIDney Disease