Actively Recruiting
SeeMe: A Multimodal Behavioral-Electrophysiological Tool for Real-Time Detection of Motor Behavior in Brain Injury Patients
Led by Stony Brook University · Updated on 2026-05-05
80
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
S
Stony Brook University
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the SeeMe platform, an automated computer vision system designed to precisely track tiny movements in patients with Traumatic Brain Injury (TBI). This interventional study aims to improve detection of voluntary motor responses that standard clinical exams often miss due to subjective observation limits. SeeMe uses advanced neural networks and synchronized brain recordings to identify early signs of motor recovery and covert awareness in TBI patients, potentially improving diagnosis and treatment planning. The study involves three groups: patients with TBI receiving daily auditory commands to evoke subtle facial and hand movements; healthy volunteers to establish normal motor response benchmarks; and sedated surgical patients to define baseline noise levels. The protocol presents five auditory commands repeatedly with randomized timing, capturing detailed video and brain activity simultaneously. Data analysis uses deep learning models to distinguish true command-following responses from reflexive movements. Participants will undergo daily assessments until hospital discharge, typically within 45 days, including synchronized video and electrophysiological recordings. Researchers will compare SeeMe's detection timing against traditional clinical scales to measure earlier identification of voluntary movement. Long-term follow-up at 6 and 12 months will track functional recovery and consciousness levels. The study includes safety oversight with patient advocates and family councils to ensure ethical communication and participant protection throughout the trial.
CONDITIONS
Brief Title
SeeMe: Using Automated Facial Tracking to Detect Voluntary Behavior in Brain Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 22 years or older with a history of acute traumatic brain injury
- Glasgow Coma Scale score less than or equal to 8 upon hospitalization
- Clinically stable as determined by primary neurosurgery or ICU team
- Intact auditory pathways confirmed by Brainstem Auditory Evoked Responses (BAERs)
- Family consent for study participation
- Adults aged 22 years or older with no history of neurological or psychiatric disorders (healthy controls)
- Normal baseline neurological examination (healthy controls)
- Ability to provide informed consent (healthy controls and sedated patients)
- Ability to follow simple auditory commands in English (healthy controls)
- Adults aged 22 years or older undergoing elective spine surgery requiring general anesthesia and pharmacological paralysis (sedated cohort)
- Clinically stable for study procedures as determined by anesthesia and surgical teams (sedated cohort)
- Intact auditory pathways (sedated cohort)
You will not qualify if you...
- Hearing impairment confirmed by absence of BAERs preventing hearing auditory commands
- No legal authorized representative available to provide consent for comatose patients
- Any medical condition deemed unsafe by the investigator
- Pregnancy
- Previous history of traumatic brain injury (for healthy controls and sedated cohort)
- Neurodegenerative diseases such as dementia
- Motor impairments interfering with facial or hand movement tracking (healthy controls)
- Significant baseline facial or hand motor deficits prior to anesthesia (sedated cohort)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Daily assessments from Day 1 until hospital discharge, typically within 45 days
Participants undergo the SeeMe multimodal auditory command protocol to detect and quantify microscopic motor responses using high-resolution video and synchronized EEG/ECoG recordings.
Daily visits for up to 45 days
Duration - 6 months and 12 months post-injury
Participants are monitored for long-term functional and consciousness recovery using established scales at 6 and 12 months post-injury.
2 follow-up visits at 6 and 12 months
Trial Site Locations
Total: 1 location
1
Stony Brook University Hospital
Stony Brook, New York, United States, 11794
Actively Recruiting
Research Team
S
Sima Mofakham, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
3
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