Actively Recruiting
Seizure Treatment in Glioma
Led by Leiden University Medical Center · Updated on 2025-02-04
120
Participants Needed
5
Research Sites
543 weeks
Total Duration
On this page
Sponsors
L
Leiden University Medical Center
Lead Sponsor
M
Medical Center Haaglanden
Collaborating Sponsor
AI-Summary
What this Trial Is About
Currently, treatment with a specific anti-epileptic drug mainly depends on the physicians' preference, as there are no studies supporting the use of one specific anticonvulsant in glioma patients. The overall aim of this randomized controlled trial is to directly compare the effectiveness of treatment with levetiracetam or valproic acid in glioma patients with a first seizure.
CONDITIONS
Official Title
Seizure Treatment in Glioma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically proven or suspected diffuse astrocytoma (IDH-1 wildtype or mutated), diffuse oligodendroglioma (IDH-1 mutated and 1p/19q co-deleted), anaplastic astrocytoma (IDH-1 wildtype or mutated), anaplastic oligodendroglioma (IDH-1 mutated and 1p/19q co-deleted), glioblastoma (IDH-1 wild-type or mutated), or diffuse astrocytoma NOS, anaplastic astrocytoma NOS, oligodendroglioma NOS, oligoastrocytoma NOS, anaplastic oligoastrocytoma NOS, anaplastic oligodendroglioma NOS or glioblastoma NOS
- Adults 18 years of age or older
- First epileptic seizure within the last 2 weeks
- Monotherapy with antiepileptic drugs is considered most appropriate at randomization
- Willing to provide written informed consent
You will not qualify if you...
- Previously treated with antiepileptic drugs, except emergency treatment in the past 2 weeks
- History of epilepsy not related to a brain tumor
- Pregnancy
- Contraindications for use of levetiracetam or valproic acid
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Amsterdam UMC
Amsterdam, Netherlands, 1007 MB
Suspended
2
Medisch Spectrum Twente
Enschede, Netherlands
Actively Recruiting
3
Leiden University Medical Center
Leiden, Netherlands, 2333 ZA
Actively Recruiting
4
Erasmus Medical Center
Rotterdam, Netherlands, 3008 AE
Actively Recruiting
5
Haaglanden Medical Center
The Hague, Netherlands, 2501 CK
Actively Recruiting
Research Team
J
Johan AF Koekkoek, MD, PhD
CONTACT
M
Monique Baas
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here