Actively Recruiting
Selective Internal Radiation Therapy With 90Y Resin Micropheres for Refractory Colorectal Cancer Liver Metastases
Led by Aarhus University Hospital · Updated on 2026-01-13
30
Participants Needed
1
Research Sites
412 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Observational, feasibility study investigating biological aspects in patients with liver metastasis from colorectal cancer undergoing treatment with SIRT, by translational analysis of biological samples.
CONDITIONS
Official Title
Selective Internal Radiation Therapy With 90Y Resin Micropheres for Refractory Colorectal Cancer Liver Metastases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of metastatic colorectal adenocarcinoma with liver dominant disease
- Liver metastasis diagnosed by histo- or cyto-pathology, or clinical and imaging criteria
- Liver metastases are not eligible for resection, RFA, or SBRT
- Off all chemotherapy treatments for at least 14 days prior to SIRT
- Off vascular endothelial growth factor inhibitors for at least 6 weeks prior to SIRT
- Progressive disease or severe intolerance after all standard chemotherapy lines
- Eastern Cooperative Oncology Group (ECOG) performance status of 0-1
- Age 18 years or older
- Able to understand written information
- Consent to provide samples for translational research
You will not qualify if you...
- Tc-99m macroaggregated albumin (MAA) scintigraphy showing extrahepatic foci in the gastrointestinal tract
- Detectable Tc-99m MAA deposition in the stomach or duodenum after angiographic techniques
- Previous radiation therapy to lungs or upper abdomen overlapping liver dose as decided by interventionist
- Lung shunt greater than 20% or lung radiation dose over 30 Gray estimated by Tc-99m MAA
- Pregnancy
- Symptomatic lung disease preventing SIRT as decided by interventionist
- Active uncontrolled infection
- Laboratory findings within 30 days showing alanine aminotransferase > 5 times normal or bilirubin > 2 mg/dl
- Evidence of ascites on CT scan or physical exam
- Tumor volume over 50% of liver volume
- Conditions preventing collection of translational samples
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Oncology, Aarhus University Hospital
Aarhus N, Danmark, Denmark, 8200
Actively Recruiting
Research Team
L
Louise B Callesen, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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