Using CUSA Clarity Device to Selectively Remove Endometriotic Tissue in Ovarian Endometriomas A Histopathological Study to Preserve Ovarian Tissue During Surgery

What this Trial Is About

Ovarian endometriomas are cysts caused by endometriosis that can harm ovarian reserve when treated with conventional surgery. This research evaluates the feasibility and tissue selectivity of a new surgical device called the Cavitron Ultrasonic Surgical Aspirator CUSA Clarity in managing these cysts. The study aims to determine if this device can selectively remove endometriotic lesions while preserving normal ovarian tissue, potentially supporting fertility-preserving surgical methods for women with ovarian endometriomas. The study observes ovarian cyst wall specimens collected during surgery from patients with ovarian endometriomas. These specimens are treated outside the body using the CUSA Clarity device at various Tissue Select settings ranging from 0 to 4. After treatment, samples undergo detailed histopathological and immunohistochemical analyses to assess how well the device removes diseased tissue and preserves healthy ovarian stroma. This approach helps evaluate the devices tissue selectivity without performing the procedure directly on patients. Participants are women aged 20 years or older undergoing surgical removal of ovarian endometriomas. After surgery, their cyst wall specimens are collected for ex vivo treatment and analysis. Researchers examine tissue samples immediately after treatment and within one week for markers indicating selective removal of endometriotic epithelium and preservation of normal ovarian tissue. The study includes histopathological confirmation, depth of tissue removal, and presence of residual lesions, with results expected to inform future fertility-friendly surgical techniques.

Selective Removal of Endometriotic Lesions Using CUSA Clarity in Ovarian Endometriomas