Actively Recruiting
Self-sampling to Optimize Anal Lesion Outcomes
Led by Medical College of Wisconsin · Updated on 2026-05-12
572
Participants Needed
3
Research Sites
175 weeks
Total Duration
On this page
Sponsors
M
Medical College of Wisconsin
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research study is to find ways to increase anal cancer screening among people at increased risk for anal cancer. This study will try to find out if persons will do an intervention (self-sampling of the anal canal) and if it affects cytology and high-resolution anoscopy (HRA) appointment attendance. Secondarily, the study will assess if a person who gets their choice of either self-sampling or healthcare provider sampling affects clinic attendance.
CONDITIONS
Official Title
Self-sampling to Optimize Anal Lesion Outcomes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 35 years or older if HIV-positive, or 45 years or older if HIV-negative
- Identify as a cisgender or transgender sexual minority man, or a transgender woman who has sex with men
- Reside in the Chicago, Houston, or Milwaukee metropolitan area
- Willing to attend a study clinic
- Speak and understand English or Spanish
- Able to understand and willing to sign a written informed consent document
You will not qualify if you...
- Previously participated in the PAC Self-Swab Study in Milwaukee
- Currently taking anticoagulants, except for aspirin or non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen
- Diagnosed with hemophilia, cirrhosis with bleeding varices, or thrombocytopenia
- Have any severe disease or condition that contraindicates participation, such as anal stenosis
- Planning to move within 12 months after enrollment
AI-Screening
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Trial Site Locations
Total: 3 locations
1
University of Chicago
Chicago, Illinois, United States, 60637
Actively Recruiting
2
The University of Texas M.D. Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
3
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
Research Team
A
Alan G Nyitray, PhD
CONTACT
J
Jenna Nitkowski, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
4
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