Actively Recruiting
Semaglutide for Smoking Cessation in Patients With Diabetes
Led by Ottawa Heart Institute Research Corporation · Updated on 2026-05-11
100
Participants Needed
1
Research Sites
71 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To assess the feasibility of conducting a randomized controlled trial (RCT) to determine the effectiveness of semaglutide as an adjunct to combination NRT in supporting smoking cessation for patients with diabetes.
CONDITIONS
Official Title
Semaglutide for Smoking Cessation in Patients With Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults (18 years or older) with type 2 diabetes
- Currently residing in Ontario
- Smoke at least five cigarettes per day and willing to reduce or quit smoking within the next 6 months
- Stable HbA1c 7.0% - 10% with no more than a 1% change over the last 3 to 6 months
- Have not used GLP-1 receptor agonists in the past six months
- Able to provide informed consent
You will not qualify if you...
- Pregnant or breastfeeding individuals
- Contraindication to nicotine replacement therapy or GLP-1 receptor agonists
- Current daily use of nicotine replacement therapy or GLP-1 receptor agonists
- Use of bupropion, cytisine, or varenicline within the last 7 days
- Use of DPP-IV inhibitor within the last 7 days
- Initiation of a new diabetes medication within the last 3 months
- Personal or family history of medullary thyroid cancer
- Personal or family history of Multiple Endocrine Neoplasia syndrome type 2
- Diabetic ketoacidosis
- Type I diabetes
- Acute pancreatitis or pancreatic cancer
- Acute, chronic, or end-stage renal failure
- Tachyarrhythmias
- Unable to engage in follow-up for any reason, for example acute mental illness, cognitive impairment, or unable to speak English or French
- Other conditions deemed by the study team to interfere with participation or outcomes, such as being acutely unwell or having a life expectancy less than 1 year
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Ottawa Heart Institute
Ottawa, Ontario, Canada, K1Y 4W7
Actively Recruiting
Research Team
E
Evyanne Quirouette
CONTACT
N
Nidhi Agrawal
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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