Actively Recruiting
Semantic and Syntactic Computerized Analysis of Free Speech to Predict Psychotic Transition
Led by University Hospital, Brest · Updated on 2026-06-02
215
Participants Needed
3
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating whether subtle speech disorganization can predict the transition to schizophrenia in patients at ultra-high risk. This longitudinal multicenter cohort study aims to identify specific language markers related to psychotic transition and validate a French predictive model using computerized speech analysis techniques. The focus is on analyzing speech patterns to better understand and predict the development of schizophrenia. Participants undergo an initial assessment including the CAARMS scale and an audio recording of their medical interview. The recorded speech is transcribed and analyzed using computerized methods such as Latent Semantic Analysis (LSA), lemmatization, vectorial analysis, and grammatical function evaluation. These analyses seek to identify linguistic markers linked to the transition to psychosis, which will be used to build a predictive model for schizophrenia. Throughout the study, researchers monitor participants for up to two years to observe any transition to schizophrenia. Data from speech analysis and clinical assessments are combined to measure outcomes. The study involves regular evaluations of participants' language and psychiatric status, aiming to improve early detection and understanding of psychosis development in at-risk individuals.
CONDITIONS
Brief Title
Semantic and Syntactic Computerized Analysis of Free Speech
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 15 and 30 years
- Experienced suicidal gesture, thought, or behavior affecting emotional, social, or professional life
- If on neuroleptic treatment impairing cognitive abilities, able to complete a one-week wash-out before assessment
- Affiliated with or beneficiary of a health insurance or social security system
- Able and willing to provide written informed consent
You will not qualify if you...
- History of psychosis
- Risk of self-harm or violence incompatible with outpatient treatment
- Intelligence quotient below 70 (WAIS)
- Presence of neurological disorder or major health problem
- Unable to interrupt neuroleptic treatment for one week
- Refusal to participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo an initial medical interview with audio recording, which is transcribed and analyzed using computerized semantic and syntactic speech analysis techniques to identify linguistic markers associated with psychotic transition.
1 baseline visit (in-person)
Duration - 2 years
Participants are observed over a 2-year period to monitor for transition to schizophrenia, using linguistic markers identified from speech analysis as potential predictors.
Periodic visits as scheduled by the study (visit frequency not specified)
Trial Site Locations
Total: 3 locations
1
CHRU de Brest
Brest, France, 29609
Actively Recruiting
2
Meunier Sophie
Caen, France
Not Yet Recruiting
3
CH de SAINT ANNE
Paris, France, 750144
Actively Recruiting
Research Team
C
Christophe LEMEY, Doctor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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