Actively Recruiting
Senescence and the Early Ageing Phenotype After Chemotherapy for Testicular Cancer: the SEA-CAT Study
Led by University Medical Center Groningen · Updated on 2024-12-13
192
Participants Needed
1
Research Sites
394 weeks
Total Duration
On this page
Sponsors
U
University Medical Center Groningen
Lead Sponsor
D
Dutch Cancer Society
Collaborating Sponsor
AI-Summary
What this Trial Is About
Cisplatin-combination chemotherapy causes inevitably DNA damage by platinum-DNA adduct formation of both tumor cells but also healthy cells. It therefore stands to reason that testicular cancer treatment causes an increased burden of senescent cells, which causes upregulation of the SASP resulting in a pro-inflammatory phenotype. The investigators hypothesize that this may be an important mechanism behind development of late effects and an early ageing phenotype after treatment for testicular cancer.
CONDITIONS
Official Title
Senescence and the Early Ageing Phenotype After Chemotherapy for Testicular Cancer: the SEA-CAT Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with metastatic testicular cancer (stage II or higher) between 1999 and 2012
- Received first-line cisplatin-based chemotherapy
- Younger than 50 years old at the start of chemotherapy
- For longitudinal study: about to start first-line cisplatin-based chemotherapy for metastatic testicular cancer
- For stage I control group: diagnosed with stage I testicular cancer
- Male participants younger than 50 years old at diagnosis
You will not qualify if you...
- Unable to provide informed consent due to mental or psychiatric disability
AI-Screening
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Trial Site Locations
Total: 1 location
1
University Medical Center Groningen
Groningen, Netherlands, 9713 GZ
Actively Recruiting
Research Team
J
J. A. Gietema, prof.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
FACTORIAL
Primary Purpose
PREVENTION
Number of Arms
3
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