Actively Recruiting

Age: 18Years - 39Years
FEMALE
Healthy Volunteers
NCT06450301

Senescent Endometrial Cells in Patients with Thin Endometrial Lining

Led by Trio Fertility · Updated on 2024-11-21

100

Participants Needed

1

Research Sites

141 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The goal of this observational study is to determine if thin endometrial lining that is unresponsive to estrogen might be associated with the presence of senescent cells in patients following long-term use of oral contraceptives. The main question it aims to answer is: Are there any senescent cells present in thin endometrial lining? During the luteal phase of the cycle, participants will will undergo: * Gynecologic US to measure the endometrial lining thickness and pattern. * Endometrial biopsy with Pipelle catheter

CONDITIONS

Official Title

Senescent Endometrial Cells in Patients with Thin Endometrial Lining

Who Can Participate

Age: 18Years - 39Years
FEMALE
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18-39
  • Body mass index (BMI) up to 35
  • Thin endometrium after oral contraceptive pill (OCP) use
  • Diagnosis of Asherman's syndrome
  • Women already undergoing endometrial biopsy for infertility testing (e.g., EMMA testing)
  • Women with archived endometrial biopsy samples
Not Eligible

You will not qualify if you...

  • Women with systemic diseases such as rheumatic disease or diabetes mellitus (DM)
  • Women with coagulopathies
  • Women with active pelvic inflammatory process
  • Women with uterine anomalies
  • Pregnant women
  • Women currently using any hormonal contraception or intrauterine device (IUD)

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Trio Fertility

Toronto, Ontario, Canada, M5G 2K4

Actively Recruiting

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How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

3

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