Actively Recruiting
Sensitivity of Repetitive Nerve Stimulation Performed in the Evening vs in the Morning in Myasthenia Gravis
Led by Jagiellonian University · Updated on 2024-10-10
40
Participants Needed
1
Research Sites
221 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Myasthenia gravis (MG) is the autoimmune disorder affecting the neuromuscular junction, characterized by fatigue, which increases gradually through the day. The repetitive nerve stimulation (RNS) remains the key diagnostic test in MG, however its sensitivity, especially in ocular form of MG is not satisfactory. In this study, investigators want to assess the impact of the time of the day on the sensitivity of the RNS. We hypothesize the RNS performed in the evening may be more sensitive than in the morning.
CONDITIONS
Official Title
Sensitivity of Repetitive Nerve Stimulation Performed in the Evening vs in the Morning in Myasthenia Gravis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with suspected or diagnosed myasthenia gravis (ocular and generalized form)
- Patients with performed or planned determination of anti-AChrR and anti-MUSK antibodies
- Disease severity of at least 1 according to the Myasthenia Gravis Foundation of America severity classification
You will not qualify if you...
- Respiratory failure
- Severe bulbar symptoms
- Use of drugs that may worsen neuromuscular transmission
- Current infection
- Peripheral nervous system diseases affecting fatigue test results, such as polyneuropathy or myopathy
- Cognitive or behavioral disorders affecting study adherence
- Use of steroids for myasthenia
- Myasthenia severity preventing safe discontinuation of acetylcholinesterase inhibitors
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Jagiellonian University Medical College, Department of Neurology
Krakow, Lesser Poland Voivodeship, Poland, 31503
Actively Recruiting
Research Team
J
Jakub M Antczak, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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