Actively Recruiting
Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol
Led by Dr. Diane Lougheed · Updated on 2025-03-20
30
Participants Needed
1
Research Sites
226 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objectives of this study are to determine the sensory-mechanical responses to Eucapneic Voluntary Hyperventilation (EVH) and Mannitol in individuals with cough variant asthma (CVA) and methacholine-induced cough with normal airway sensitivity (COUGH) and compare these responses to a control group of healthy individuals without asthma or chronic cough. We hypothesize: 1. EVH and Mannitol cause dyspnea, cough, small airway obstruction with resultant dynamic hyperinflation, gas trapping and autoPEEP in individuals with CVA and COUGH, but not healthy controls. 2. The sensory-mechanical responses to both hyperosmolar challenges (EVH and Mannitol) are comparable within groups (CVA, COUGH and healthy controls).
CONDITIONS
Official Title
Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals aged 18 to 65 years with cough variant asthma (CVA) or methacholine-induced cough with normal airway sensitivity
- CVA defined as chronic cough lasting 8 weeks or more, positive methacholine challenge (PC20 ≤ 16 mg/mL), and history of cough responding to asthma treatment
- Methacholine-induced cough with normal airway sensitivity defined as chronic cough lasting 8 weeks or more and negative methacholine challenge (PC20 > 16 mg/mL)
- Individuals aged 18 to 65 years with no history of asthma or chronic cough
You will not qualify if you...
- Exacerbation requiring medication change, emergency visit, or hospitalization within the past 4 weeks
- Inability to perform acceptable spirometry
- Medical contraindications to methacholine challenge testing
- Smoking history exceeding 10 pack years
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Kingston Health Sciences Centre
Kingston, Ontario, Canada, K7L 2V7
Actively Recruiting
Research Team
M
M. Diane Lougheed, MD, MSc
CONTACT
T
Taylar Wall, RRT
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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