Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.
M Matsuda, R A DeFronzo
https://pubmed.ncbi.nlm.nih.gov/10480510Actively Recruiting
Led by Nana Gletsu Miller · Updated on 2025-10-31
63
Participants Needed
3
Research Sites
N/A
Total Duration
N
Nana Gletsu Miller
Lead Sponsor
P
Purdue University
Collaborating Sponsor
This research aims to evaluate whether replacing sugary sodas with unsweetened, flavored sparkling waters can reduce added sugar intake and improve health among Black/African American and Latine adolescents with obesity who prefer sweet-tasting beverages. The study focuses on adolescents aged 12 to 18 who are "sweet-likers," meaning they prefer higher sugar concentrations in drinks. The main questions explore if changing beverage choices affects liking for sugary drinks and water, and whether this leads to better diet quality and cardiometabolic health. Participants will be randomly assigned to one of three groups for a 4-week intervention: replacing sodas with flavored unsweetened sparkling water, replacing sodas with beverages that gradually reduce sugar concentration weekly until unsweetened sparkling water, or replacing sodas with plain still water as a control. Following the intervention, there is a 4-week follow-up period to track changes. All sugary sodas will be replaced with assigned study beverages during the intervention. Throughout the 8 weeks, participants will complete taste tests to measure their liking and perception of sweetness at baseline, week 2, week 4, and week 8. Researchers will collect dietary recalls, body measurements like height, weight, and waist circumference, blood pressure, and blood samples to measure glucose, insulin, and triglycerides at baseline, week 4, and week 8. The study aims to see if changes in sweetness preference relate to improvements in health markers and diet quality while monitoring participant compliance and any side effects.
CONDITIONS
A Sensory Strategy to Cut Sugary Beverages in African/American and Latine Adolescents
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 4 weeks
Participants replace their usual sugary sodas with assigned study beverages for 4 weeks. Depending on their group, they will consume either flavored unsweetened sparkling water, progressively reduced sugar beverages, or plain still water.
Baseline visit and visits at Week 2 and Week 4
Duration - 4 weeks
Participants continue to be monitored for changes in beverage liking, diet quality, and cardiometabolic markers during a 4-week post-intervention period.
1 visit at Week 8
Total: 3 locations
1
Indiana University School of Public Health - Bloomington
Bloomington, Indiana, United States, 47405
Not Yet Recruiting
2
Indiana University Hospital
Indianapolis, Indiana, United States, 46202
Actively Recruiting
3
Purdue University
West Lafayette, Indiana, United States, 47907
Actively Recruiting
N
Nana Gletsu Miller, PhD
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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