Actively Recruiting

Early Phase 1
Age: 21Years - 55Years
All Genders
Healthy Volunteers
NCT06816459

Sensory Tests of Cigarettes for Identification of Flavors in Current Daily Smoking Adults

Led by Roswell Park Cancer Institute · Updated on 2026-04-06

30

Participants Needed

1

Research Sites

104 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This clinical trial tests how well current daily smoking adults can identify flavors of cigarettes. Menthol cigarettes account for 31 percent of cigarettes sold in the United States. Flavors such as menthol play an important role in the start and continued use of tobacco products. Two ways users experience flavor is through smell and taste. Menthol has cooling and numbing properties that can increase perceptions of smoothness and reduce the perceived harshness of smoke. Menthol adds a taste and aroma commonly described as "minty". The effect of menthol flavoring on smoking behavior has been studied. Use of menthol cigarettes has been associated with greater nicotine dependence and is associated with both fewer quit attempts and lower odds of quit success. In 2022, the Food and Drug Administration proposed to restrict the use of menthol as a flavor in cigarettes. Menthol has already been banned in Canada, the United Kingdom and the European Union. In late 2022, a restriction on all flavored tobacco products went into effect in California (CA), prompting the tobacco industry to introduce substitute products that did not contain menthol. It is important to find out whether New York (NY) adult smokers who smoke menthol cigarettes can identify and characterize flavors in the same cigarette brand as sold in NY versus CA following the ban of menthol cigarettes in 2022.

CONDITIONS

Official Title

Sensory Tests of Cigarettes for Identification of Flavors in Current Daily Smoking Adults

Who Can Participate

Age: 21Years - 55Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Aged 21-55 years old
  • Current daily smoker of factory-made menthol cigarettes
  • General good health as self-reported
  • Completion of Brief Smell Identification Test with no smell deficits
Not Eligible

You will not qualify if you...

  • Daily use of other tobacco products such as e-cigarettes, cigars, or smokeless tobacco
  • Known allergies to mint or menthol
  • Self-reported problems with smell or taste
  • Pregnant or nursing
  • Use of medications that affect sense of smell
  • Positive COVID-19 diagnosis within 10 days before enrollment
  • Current upper respiratory infection or sinus congestion

AI-Screening

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Trial Site Locations

Total: 1 location

1

Roswell Park Cancer Institute

Buffalo, New York, United States, 14263

Actively Recruiting

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How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

BASIC_SCIENCE

Number of Arms

2

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