Actively Recruiting
Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD)
Led by First Affiliated Hospital of Chongqing Medical University · Updated on 2026-01-27
520
Participants Needed
1
Research Sites
227 weeks
Total Duration
On this page
Sponsors
F
First Affiliated Hospital of Chongqing Medical University
Lead Sponsor
T
The Second Affiliated Hospital of Chongqing Medical University
Collaborating Sponsor
AI-Summary
What this Trial Is About
This project aims to investigate the effectiveness of existing common antidepressants and to provide new evidence for depressed children and adolescents who are not responding to their first treatment.
CONDITIONS
Official Title
Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 13 to 18 years
- Diagnosed with major depressive disorder (MDD) with non-psychotic symptoms according to DSM-V
- Score of 40 or higher on the Children's Depression Rating Scale (CDRS-R)
- Participants with suicidal thoughts can join if outpatient treatment is safe
- Sufficient audio-visual ability to participate in the study
- Written informed consent from the participant and at least one parent
You will not qualify if you...
- History of bipolar disorder, schizophrenia, autism, eating disorders, primary obsessive compulsive disorder, pervasive developmental disorder, or unspecified psychosis
- Serious physical illnesses
- Substance abuse or dependence
- Current depression with clear suicidal plans or behavior
- Need for inpatient psychiatric treatment
- Severe mental disorders requiring intensive care
- Two or more failed antidepressant trials lasting at least 8 weeks each with full dose for the last 4 weeks
- History of intolerance or lack of effect from at least one treatment option in the study
- Taking medicines that interfere with study treatments
- Use of antidepressants within 5 half-lives prior to study
- Received modified electroconvulsive therapy within the past 12 months
- Pregnant females
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Chongqing Medical University
Chongqing, Province, China, 400000
Actively Recruiting
Research Team
X
Xinyu Zhou
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
8
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